STATISTICS　IN　MEDICINE
Statist.　Med.　17,　1231-1243(1998)

ＥSTIMATION OF AGE-SPECIFIC REFERENCE RANGES
VIA SMOOTHER AVAS


TOSHIRO TANGO
Division of  Theoretical Epidemiology , The Institute of Public Health,
4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan
　　

SUMMAY
This paper proposes a new non-parametric procedure to estimate age-dependent reference rangs based on Tibshirani's AVAS (additivity and variance stabilization) procedure for non-parametric estimation of  transformations for regression. Several examples are given to illustrate the flexibility and applicability of the proposed method; thses include alkaline phosphatase in girls,and foot length and head circumference during gestation. © 1998 John Wiley & Sons, Ltd.