\u5929\u7136\u75d8\u306e\u75c5\u539f\u4f53\u306f\u3001\u5929\u7136\u75d8\uff08\u75d8\u7621\uff09\u30a6\u30a4\u30eb\u30b9\uff08Variola virus<\/i>\uff09\u3067\u3042\u308a\u3001\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u79d1\uff08Poxviridae\uff09\u306e\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u5c5e\uff08Genus Orthopox\uff09\u306b\u5206\u985e\u3055\u308c\u308b\u3002\u725b\u75d8\u30a6\u30a4\u30eb\u30b9\u3001\u30ef\u30af\u30b7\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u3001\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u3082\u3001\u3053\u306e\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u5c5e\u306b\u542b\u307e\u308c\u308b\u3002\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u3092\u6709\u3059\u308b\u5927\u578b\uff08150nm\u301c260nm\uff09\u306e\u4e8c\u672c\u9396DNA\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308b\u3002\u81ea\u7136\u754c\u306e\u4e2d\u3067\u306f\u6bd4\u8f03\u7684\u5b89\u5b9a\u3067\u3001\u4f4e\u6e29\u3084\u4e7e\u71e5\u306b\u5f37\u304f\u3001\u30a8\u30a2\u30ed\u30be\u30eb\u306e\u72b6\u614b\u3067\u3082\u5c11\u306a\u304f\u3068\u3082\u6570\u6642\u9593\u306f\u611f\u67d3\u529b\u3092\u6709\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u305f\u3060\u3057\u3001\u7d2b\u5916\u7dda\u3084\u30a2\u30eb\u30b3\u30fc\u30eb\u3001\u30db\u30eb\u30de\u30ea\u30f3\uff08\u30a8\u30fc\u30c6\u30eb\u306b\u306f\u8010\u6027\uff09\u306b\u3088\u3063\u3066\u5bb9\u6613\u306b\u4e0d\u6d3b\u5316\u3055\u308c\u308b\u3002\u4eba\u9593\u304c\u552f\u4e00\u306e\u81ea\u7136\u5bbf\u4e3b\u3067\u3042\u308a\u3001\u52d5\u7269\u3084\u6606\u866b\u306a\u3069\u306b\u3088\u3063\u3066\u306f\u5a92\u4ecb\u3055\u308c\u306a\u3044\u3002<\/p>\n
\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u81e8\u5e8a\u7684\u306bvariola major\u3068variola minor\u306e\uff12\u3064\u306b\u5927\u5225\u3055\u308c\u308b\u3002Variola major\u306b\u3088\u308b\u5929\u7136\u75d8\u306f\u3055\u3089\u306b\u3001ordinary\uff08\u901a\u5e38\u578b\uff1a90%\u4ee5\u4e0a\u304c\u3053\u306e\u30bf\u30a4\u30d7\uff09\u3001modified\uff08\u8efd\u75c7\u578b\uff1a\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u8005\u306b\u8d77\u3053\u308b\u8efd\u75c7\u578b\uff09\u3001flat\uff08\u6241\u5e73\u578b\uff09\u304a\u3088\u3073hemorrhagic\uff08\u51fa\u8840\u6027\uff09\uff08\u4e21\u578b\u3068\u3082\u7a00\u3067\u306f\u3042\u308b\u304c\u3001\u6975\u3081\u3066\u91cd\u75c7\u3067\u307b\u307c\u81f4\u6b7b\u6027\uff09\u306e\uff14\u3064\u306e\u578b\u306b\u5206\u3051\u3089\u308c\u3066\u3044\u308b\u3002\u81f4\u6b7b\u7387\u306fvariola major\u5168\u4f53\u3067\u306f\u7d0430%\uff0820\u301c50%\uff09\u3001variola minor\u3067\u306f1%\u4ee5\u4e0b\u3067\u3042\u308b\u3002<\/p>\n
1956\u5e74\u4ee5\u964d\u3001\u65e5\u672c\u56fd\u5185\u3067\u306f\u5929\u7136\u75d8\u306e\u767a\u751f\u306f\u306a\u304f\u30011976\u5e74\u306b\u306f\u30ef\u30af\u30c1\u30f3\u306e\u5b9a\u671f\u63a5\u7a2e\u3082\u4e8b\u5b9f\u4e0a\u4e2d\u6b62\u3055\u308c\u305f\u3002\u4e16\u754c\u4e2d\u3067\u30821977\u5e74\u306e\u30bd\u30de\u30ea\u30a2\u306b\u304a\u3051\u308b\u60a3\u8005\u304c\u6700\u5f8c\u3067\u3042\u308a\u30011980\u5e745\u6708\u306b\u306fWHO\u304c\u5929\u7136\u75d8\u306e\u4e16\u754c\u6839\u7d76\u5ba3\u8a00\u3092\u51fa\u3057\u3066\u3044\u308b\u3002\u73fe\u5728\u3001\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u306f\u7c73\u56fd\u3068\u30ed\u30b7\u30a2\u306e\u30d0\u30a4\u30aa\u30bb\u30fc\u30d5\u30c6\u30a3\u30ec\u30d9\u30eb\uff14(BSL-4)\u306e\u65bd\u8a2d\u306e\u307f\u3067\u53b3\u91cd\u306b\u4fdd\u7ba1\u3055\u308c\u3066\u3044\u308b\u3068\u516c\u8868\u3055\u308c\u3066\u306f\u3044\u308b\u304c\u3001\u30d0\u30a4\u30aa\u30c6\u30ed\u306b\u7528\u3044\u3089\u308c\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u751f\u7269\u5175\u5668\u3068\u3057\u3066\u306f\u3001\u70ad\u75bd\u83cc\u3068\u306a\u3089\u3093\u3067\u6700\u3082\u91cd\u8981\u306a\u75c5\u539f\u4f53\u3067\u3042\u308b\u3002CDC\u306e\u751f\u7269\u5175\u5668\u30ab\u30c6\u30b4\u30ea\u30fc\u5206\u985e\u3067\u3082\u3001\u30ab\u30c6\u30b4\u30ea\u30fcA\u306b\u5206\u985e\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n
\u25b2TOP<\/a><\/p>\n\u4e3b\u306a\u81e8\u5e8a\u50cf<\/h3>\n
\n
\n
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\u5199\u771f5\uff09\u3002\u5929\u7136\u75d8\u3067\u307f\u3089\u308c\u308b\u4e00\u9023\u306e\u767a\u75b9\u306f\u3001\u6c34\u75d8\u306e\u3088\u3046\u306b\u5404\u6642\u671f\u306e\u767a\u75b9\u304c\u540c\u6642\u306b\u898b\u3089\u308c\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u305d\u306e\u6642\u671f\u306b\u898b\u3089\u308c\u308b\u767a\u75b9\u306f\u3059\u3079\u3066\u540c\u4e00\u3067\u3042\u308b\u3053\u3068\u304c\u7279\u5fb4\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\u25b2TOP<\/a><\/p>\n\u81e8\u5e8a\u691c\u67fb\u6240\u898b<\/h3>\n\u8840\u6db2\u751f\u5316\u5b66\u691c\u67fb<\/h3>\n\u5929\u7136\u75d8\u306b\u95a2\u3059\u308b\u8840\u6db2\u751f\u5316\u5b66\u6240\u898b\u306b\u3064\u3044\u3066\u306f\u8a73\u7d30\u4e0d\u660e\u3002<\/p>\n\u753b\u50cf\u691c\u67fb\u305d\u306e\u4ed6<\/h3>\n\u5929\u7136\u75d8\u306b\u7279\u5fb4\u7684\u306a\u753b\u50cf\u6240\u898b\u7b49\u306f\u306a\u3044\u3002<\/p>\n\u25b2TOP<\/a><\/p>\n\u78ba\u5b9a\u8a3a\u65ad<\/h3>\n\u691c\u4f53\u306e\u63a1\u53d6\u3001\u8f38\u9001\u3001\u4fdd\u5b58\u306a\u3069<\/h5>\n\u5929\u7136\u75d8\u306e\u78ba\u5b9a\u8a3a\u65ad\u306b\u306f\u5b9f\u9a13\u5ba4\u8a3a\u65ad\u306b\u3088\u308b\u75c5\u539f\u8a3a\u65ad\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u533b\u5e2b\u304c\u81e8\u5e8a\u7684\u306b\u5929\u7136\u75d8\u3092\u7591\u3063\u305f\u5834\u5408\u3001\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240 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\u304c\u5bfe\u5fdc\u3059\u308b\u3002<\/p>\n\u75c5\u671f\u306b\u3088\u308b\u691c\u4f53\u306e\u9078\u629e<\/h5>\n\u5929\u7136\u75d8\u306e\u75c5\u671f\u306b\u3088\u3063\u3066\u53ef\u80fd\u306a\u691c\u67fb\u304c\u7570\u306a\u308b\u305f\u3081\u5fc5\u8981\u306a\u691c\u4f53\u3082\u75c5\u671f\u306b\u3088\u308a\u7570\u306a\u308b\u3002\u4ee5\u4e0b\u306e\u8868\u306b\u5f93\u3063\u3066\u75c5\u671f\u306b\u3088\u3063\u3066\u63a1\u53d6\u3059\u308b\u691c\u4f53\u3092\u9078\u629e\u3059\u308b\u3002<\/p>\n\n\n\n\n\n\n\n\u75c5\u671f<\/td>\n\u691c\u4f53<\/td>\n\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u691c\u51fa\uff08\u96fb\u9855\uff09<\/td>\n\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u691c\u51fa<\/td>\n\u30a6\u30a4\u30eb\u30b9\u6297\u4f53\u691c\u51fa<\/td>\n<\/tr>\n\n\u6f5c\u4f0f\u671f\u524d\u99c6\u671f<\/td>\n\u8840\u6db2<\/td>\n–<\/td>\n+\/-<\/td>\n–<\/td>\n<\/tr>\n\n\u4e18\u75b9\u671f\u304a\u3088\u3073\u7d05\u6591\u671f<\/td>\n\u5857\u62b9\u6a19\u672c<\/td>\n+<\/td>\n–<\/td>\n+<\/td>\n<\/tr>\n\n<\/td>\n\u8840\u6e05<\/td>\n–<\/td>\n–<\/td>\n–<\/td>\n<\/tr>\n\n\u6c34\u75b1\u671f<\/td>\n\u5857\u62b9\u6a19\u672c<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n<\/tr>\n\n<\/td>\n\u6c34\u75b1\u6db2<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n<\/tr>\n\n<\/td>\n\u8840\u6e05<\/td>\n–<\/td>\n–<\/td>\n+\/-<\/td>\n<\/tr>\n\n\u81bf\u75b1\u671f<\/td>\n\u5857\u62b9\u6a19\u672c<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n<\/tr>\n\n<\/td>\n\u81bf\u75b1\u6db2<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n<\/tr>\n\n<\/td>\n\u8840\u6e05<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n<\/tr>\n\n\u75c2\u76ae\u671f<\/td>\n\u75c2\u76ae<\/td>\n+<\/td>\n+<\/td>\n–<\/td>\n<\/tr>\n\n<\/td>\n\u8840\u6e05<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n<\/tr>\n\n\u56de\u5fa9\u671f<\/td>\n\u8840\u6e05<\/td>\n–<\/td>\n–<\/td>\n+<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\u691c\u4f53\u306e\u63a1\u53d6\u6cd5<\/h5>\n\n\u8840\u6db2\uff1a\u30d8\u30d1\u30ea\u30f3\u8840\u30925ml<\/li>\n\u5857\u62b9\u6a19\u672c\uff1a\n\u5b89\u5168\u30ad\u30e3\u30d3\u30cd\u30c3\u30c8\u7b49\u306e\u8a2d\u5099\u304c\u7121\u3044\u5834\u5408\u306f\u3001\u4e0a\u84cb\u3092\u3068\u308a2ml\u306e\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u30c1\u30e5\u30fc\u30d6\u306b\u5165\u308c\u3066\u5bc6\u6813\u3057\u3066\u51b7\u5374\u3057\u3066\uff08\u51cd\u7d50\u306f\u3057\u306a\u3044\uff09\u3001\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u3078\u904b\u642c\u3059\u308b\u3002\n\u53ef\u80fd\u306a\u5834\u5408\u306f\u3001\u4e0a\u84cb\u3092\u3068\u308a\u3001\u305d\u306e\u5185\u5074\u3092\u30b9\u30e9\u30a4\u30c9\u30b0\u30e9\u30b9\u306b\u30b9\u30e1\u30a2\u3057\u4e7e\u71e5\u3059\u308b\u3002\u30b9\u30e1\u30a2\u6a19\u672c\u30923\u306a\u3044\u30574\u679a\u4f5c\u6210\u3059\u308b\u3002\u3046\u307e\u304f\u4e0a\u84cb\u304c\u3068\u308c\u306a\u3044\u304b\u3001\u75b1\u5e95\u304c\u6e7f\u6027\u3092\u304a\u3073\u3066\u3044\u308b\u3068\u304d\u306f\u3001\u30b9\u30e9\u30a4\u30c9\u30b0\u30e9\u30b9\u306e\u8868\u9762\u3092\u62bc\u3057\u4ed8\u3051\u3066\u30b9\u30e1\u30a2\u3092\u53d6\u308b\uff08\u56f34<\/a> 3-1\uff09\u3002\u5857\u62b9\u6a19\u672c\u306f\u30a6\u30a4\u30eb\u30b9\u304c\u4e0d\u6d3b\u5316\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u3067\u30b9\u30e9\u30a4\u30c9\u30b0\u30e9\u30b9\u30b1\u30fc\u30b9(\u30d7\u30e9\u30b9\u30c6\u30a3\u30c3\u30af\u88fd\u306e25\u679a\u7a0b\u5ea6\u5165\u308b\u3082\u306e)\u306b\u5165\u308c\u30c6\u30fc\u30d7\u7b49\u3067\u5bc6\u9589\u3057\u3001\u3055\u3089\u306b\u30d3\u30cb\u30fc\u30eb\u888b\u7b49\u306b\u5165\u308c\u3066\u30c6\u30fc\u30d4\u30f3\u30b0\u3059\u308b\u3002\u51b7\u5374\u72b6\u614b\u3092\u4fdd\u3063\u3066\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u3078\u904b\u3076\u3002\u51cd\u7d50\u306f\u4e0d\u53ef\u3002<\/li>\n\u6c34\u75b1\u6db2\u30fb\u81bf\u75b1\u6db2\uff1a\nPBS\u30920.1\u301c0.2ml\u5165\u308c\u305f\u6ce8\u5c04\u91dd(26\uff27)\u4ed8\u304d\u306e1ml\u306e\u6ce8\u5c04\u5668\uff08\u30c4\u30d9\u30eb\u30af\u30ea\u30f3\u7528\uff09\u3092\u75b1\u819c\u304b\u3089\u633f\u5165\u3057\u3066\u30012\u301c3\u56de\u30dd\u30f3\u30d4\u30f3\u30b0\u3057\u3066\u5185\u5bb9\u6db2\u3092\u63a1\u53d6\u3059\u308b\uff08\u56f34<\/a> 3-2\uff09\u3002\u30bb\u30e9\u30e0\u30c1\u30e5\u30fc\u30d6\u7b49\u306b\u5185\u5bb9\u6db2\u3092\u5165\u308c\u3066\u30014\u2103\u306b\u51b7\u5374\u3057\u3066\u611f\u67d3\u7814\u3078\u904b\u3076\u3002<\/li>\n\u75c2\u76ae\uff1a\n\u30d4\u30f3\u30bb\u30c3\u30c8\u3067\u75c2\u76ae\u3092\u63a1\u53d6\u3057\uff08\u56f34<\/a> 3-3\uff09\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u30c1\u30e5\u30fc\u30d6\u7b49\u306b\u5165\u308c\u3066\u5bc6\u6813\u3057\u30014\u00baC\u306b\u51b7\u5374\u3057\u3066\u611f\u67d3\u7814\u3078\u904b\u3076\u3002<\/li>\n\u8840\u6e05\uff1a\n\u5b89\u5168\u30ad\u30e3\u30d3\u30cd\u30c3\u30c8\u7b49\u306e\u8a2d\u5099\u304c\u7121\u3044\u5834\u5408\u3001\u51dd\u56fa\u8840\u6db2\u3092\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u306b\u904b\u3076\u3002\u53ef\u80fd\u306a\u5834\u5408\u306f\u5e38\u6cd5\u306b\u3088\u308b\u3002\u305f\u3060\u3057\u3001\u8840\u6db2\u51dd\u56fa\u584a\u3001\u8840\u6db2\u4e2d\u306b\u30a6\u30a4\u30eb\u30b9\u304c\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u8840\u6e05\u5206\u96e2\u7b49\u306b\u7528\u3044\u305f\u8a66\u9a13\u7ba1\u3001\u30d4\u30da\u30c3\u30c8\u3001\u8840\u6db2\u51dd\u56fa\u584a\u7b49\u306f\u5fc5\u305a\u30aa\u30fc\u30c8\u30af\u30ec\u30fc\u30d6\u51e6\u7406\u3059\u308b\u3002\u8840\u6e05\u306f\u3001\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u3078\u904b\u3076\u3002<\/li>\n\u691c\u4f53\u306e\u5305\u88c5\u7b49\uff1a\n\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u306e\u300c\u611f\u67d3\u6027\u6750\u6599\uff08\u75c5\u539f\u4f53\u7b49\u53ca\u3073\u8a3a\u65ad\u7528\u306e\u30d2\u30c8\u3042\u308b\u3044\u306f\u52d5\u7269\u306e\u691c\u4f53\uff09\u306e\u8f38\u9001\u306b\u95a2\u3059\u308b\u30de\u30cb\u30e5\u30a2\u30eb\uff08\u6301\u53c2\u306e\u5834\u5408\uff09\u300d\uff08\u554f\u3044\u5408\u308f\u305b\u5148\uff1a\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240 \u696d\u52d9\u8ab2 TEL: 03-5285-1111\uff09\u306b\u5f93\u3063\u3066\u3001\u57fa\u672c\u578b\u4e09\u91cd\u5305\u88c5\u5bb9\u5668\u306b\u691c\u4f53\u3092\u5165\u308c\u308b\uff08\u300c\u30a6\u30a4\u30eb\u30b9\u6027\u51fa\u8840\u71b1\u300d\u306e\u9805\u53c2\u7167\uff09\u3002\u691c\u4f53\u306f\u3001\u5fc5\u305a\u6301\u53c2\u3059\u308b\u3002<\/li>\n<\/ol>\n\u5fae\u751f\u7269\u5b66\u7684\u691c\u67fb\u6cd5<\/h4>\n\n\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u9023\u9396\u53cd\u5fdc (PCR)\uff1a\nPCR\u6cd5\u3067\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u306e\u691c\u51fa\u3092\u884c\u3046\u3002<\/li>\n\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u691c\u51fa\u86cd\u5149\u6297\u4f53\u6cd5\uff1a\n\u5857\u62b9\u6a19\u672c\u3092\u30a2\u30bb\u30c8\u30f3\u3067\u5ba4\u6e2910\u5206\u9593\u56fa\u5b9a\u3057\u305f\u3082\u306e\u3092\u7528\u3044\u308b\u3002\u6297\u30ef\u30af\u30c1\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u30a6\u30b5\u30ae\u8840\u6e05\u3092\uff11\u6b21\u8840\u6e05\u3068\u3057\u3066\u3001FITC\u6a19\u8b58\u6297\u30a6\u30b5\u30aeIgG\u6297\u4f53\u3092\uff12\u6b21\u8840\u6e05\u306b\u7528\u3044\u3066\u9593\u63a5\u86cd\u5149\u6297\u4f53\u6cd5\u3092\u884c\u3046\u3002\u3053\u306e\u65b9\u6cd5\u3067\u306f\u3001\u691c\u4f53\uff08\u5857\u62b9\u6a19\u672c\uff09\u306b\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u306e\u5b58\u5728\u3092\u78ba\u5b9a\u3067\u304d\u308b\u304c\uff08\u56f35<\/a>\uff09\u3001\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u3068\u305d\u306e\u4ed6\u306e\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u306e\u9451\u5225\u306f\u3067\u304d\u306a\u3044\u3002\uff11\u6b21\u8840\u6e05\u306b\u6297VZV\uff08\u6c34\u75d8\u30a6\u30a4\u30eb\u30b9\uff09\u6297\u4f53\u3092\u7528\u3044\u308b\u3068\u6c34\u75d8\u3068\u306e\u9451\u5225\u306f\u3067\u304d\u308b\u3002<\/li>\n\u96fb\u5b50\u9855\u5fae\u93e1\u306b\u3088\u308b\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u306e\u691c\u51fa\u30fb\u540c\u5b9a\uff08\u56f36<\/a>\uff09\uff1a<\/li>\n<\/ol>\n\u691c\u4f53\uff08\u6c34\u75b1\u6db2\u3001\u81bf\u75b1\u6db2\u3001\u75c2\u76ae\u4e73\u5264\uff09\u3092\u5bfe\u8c61\u306b\u30ea\u30f3\u30bf\u30f3\u30b0\u30b9\u30c6\u30f3\u9178\u306b\u3088\u308b\u30cd\u30ac\u30c6\u30a3\u30d6\u67d3\u8272\u5f8c\u306b\u96fb\u5b50\u9855\u5fae\u93e1\u89b3\u5bdf\u3057\u3066\u3001\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u306e\u691c\u51fa\u3092\u884c\u3046\u3002\u3053\u306e\u691c\u67fb\u3067\u306f\u3001\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u3068\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u3001\u30ef\u30af\u30c1\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u7b49\u306e\u4ed6\u306e\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u3068\u306f\u9451\u5225\u3067\u304d\u306a\u3044\u3002\u6c34\u75d8\u60a3\u8005\u691c\u4f53\u306b\u307f\u3089\u308c\u308b\u6c34\u75d8\u30a6\u30a4\u30eb\u30b9\uff08\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\uff09\u3068\u306f\u5bb9\u6613\u306b\u8b58\u5225\u3067\u304d\u308b\u3002<\/p>\n\u8a3a\u65ad\u57fa\u6e96\uff1a<\/h5>\n\u4e0a\u8a18\u306e\u5b9f\u9a13\u5ba4\u8a3a\u65ad\u6cd5\u306b\u3088\u308b\u691c\u67fb\u3067\u3001\u4ee5\u4e0b\u306e\u3044\u305a\u308c\u304b\u304c\u6e80\u305f\u3055\u308c\u305f\u5834\u5408\u3001\u5929\u7136\u75d8\u3068\u3059\u308b\u3002<\/p>\n\n\u88ab\u9a13\u691c\u4f53\u304b\u3089\u300c\u8a3a\u65ad\u306e\u305f\u3081\u306e\u57f9\u990a\u300d\u3067\u75d8\u305d\u3046\u30a6\u30a4\u30eb\u30b9\u304c\u540c\u5b9a\u3055\u308c\u305f\uff08\u3053\u306e\u691c\u67fb\u306b\u306fBSL4\u5b9f\u9a13\u5ba4\u306e\u7a3c\u50cd\u304c\u5fc5\u8981\uff09\u3002<\/li>\n\u88ab\u9a13\u691c\u4f53\u304b\u3089\u300cPCR\u6cd5\u300d\u3067\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u304c\u691c\u51fa\u3055\u308c\u305f\u3002<\/li>\n<\/ul>\n\u307e\u305f\u3001\u6b21\u306e\u5834\u5408\u306f\u300c\u5929\u7136\u75d8\u300d\u3092\u7591\u3046\u3002<\/p>\n\n\u88ab\u9a13\u691c\u4f53\u304b\u3089\u300c\u96fb\u5b50\u9855\u5fae\u93e1\u89b3\u5bdf\u300d\u3067\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u304c\u691c\u51fa\u3055\u308c\u305f\u3002<\/li>\n\u88ab\u9a13\u691c\u4f53\u304b\u3089\u300c\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u691c\u51fa\u86cd\u5149\u6297\u4f53\u6cd5\u300d\u3067\uff0c\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u86cb\u767d\u304c\u691c\u51fa\u3055\u308c\u305f\u3002<\/li>\n<\/ul>\n\u25b2TOP<\/a><\/p>\n\u6cbb\u7642<\/h3>\n\u85ac\u7269\u7642\u6cd5\uff08\u6297\u83cc\u85ac\u7642\u6cd5\uff09<\/h4>\n\u30a6\u30a4\u30eb\u30b9\u66dd\u9732\u5f8c4\u65e5\u76ee\u4ee5\u5185\u3067\u3042\u308c\u3070\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306b\u3088\u308a\u8efd\u75c7\u5316\u307e\u305f\u306f\u767a\u75c5\u4e88\u9632\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u3002\u307e\u305f\u3001\u66dd\u9732\u5f8c1\u9031\u9593\u4ee5\u5185\u3067\u3042\u308c\u3070\u3001\u3042\u308b\u7a0b\u5ea6\u306e\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3053\u3068\u304c\u7d4c\u9a13\u7684\u306b\u77e5\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u66dd\u9732\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u5b9f\u3067\u3042\u308b\u5834\u5408\u306b\u306f\u3001\u767a\u75c7\u524d\u3067\u3042\u308c\u3070\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u8a66\u307f\u308b\u4fa1\u5024\u306f\u3042\u308b\u3068\u601d\u308f\u308c\u308b\u3002<\/p>\n\u9577\u304f\u3001\u7279\u7570\u7684\u306a\u6cbb\u7642\u85ac\u306f\u306a\u304f\u3001\u767a\u75c7\u5f8c\u306e\u6cbb\u7642\u306f\u5bfe\u8c61\u7642\u6cd5\u304c\u4e2d\u5fc3\u3068\u306a\u3063\u3066\u3044\u305f\u304c\u3001\u7c73\u56fd\u3067\u306f2018\u5e74\u306bTpoxx (\u30c6\u30b3\u30d3\u30ea\u30de\u30c3\u30c8 : Tecovirimat)\u30012021\u5e74\u306b\u30d6\u30ea\u30f3\u30b7\u30c9\u30d5\u30a9\u30d3\u30eb(Brincidofovir:BCV, Chimerix Inc.)\u304cFDA\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u65e5\u672c\u56fd\u5185\u306e\u627f\u8a8d\u85ac\u306f\u306a\u3044\u304c\u3001\u5b9f\u969b\u306b\u672c\u75be\u60a3\u306b\u906d\u9047\u3059\u308b\u3053\u3068\u306b\u306a\u3063\u305f\u5834\u5408\u306f\u3001\u305d\u306e\u6642\u70b9\u3067\u306e\u6d77\u5916\u306e\u627f\u8a8d\u85ac\u306e\u56fd\u5185\u3067\u306e\u5165\u624b\u72b6\u6cc1\u3092\u8abf\u3079\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u91cd\u75c7\u4f8b\u306b\u304a\u3044\u3066\u306f\u3001\u65e9\u671f\u306b\u306f\u93ae\u75db\u5264\u6295\u4e0e\u3001\u6c34\u5206\u88dc\u7d66\u3001\u6804\u990a\u88dc\u7d66\u53ca\u3073\u6c17\u9053\u78ba\u4fdd\uff08\u4e0a\u6c17\u9053\u6d6e\u816b\u306b\u3088\u308b\u6c17\u9053\u9589\u585e\u306e\u304a\u305d\u308c\u304c\u3042\u308b\u5834\u5408\u306f\u30d2\u30c9\u30ed\u30b3\u30eb\u30c1\u30be\u30f3\u3092\u6295\u4e0e\uff09\u3001\u767a\u75b9\u671f\u306b\u306f\u76ae\u819a\u306e\u885b\u751f\u4fdd\u6301\u3001\u767a\u75b9\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u3092\u304a\u3053\u306a\u3046\u3002\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u30b7\u30c9\u30d5\u30a9\u30d3\u30eb\u306e\u81e8\u5e8a\u7684\u306a\u6709\u7528\u6027\u3092\u793a\u3059\u30c7\u30fc\u30bf\u306f\u306a\u3044\u304c\u3001in vitro\u3084\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u306f\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u306b\u6d3b\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001BCV\u306f\u30b7\u30c9\u30d5\u30a9\u30d3\u30eb\u306e\u8102\u8cea\u7d50\u5408\u4f53\u3067\u3042\u308b\u3002\u814e\u969c\u5bb3\u3084\u597d\u4e2d\u7403\u6e1b\u5c11\u306a\u3069\u306e\u526f\u4f5c\u7528\u3082\u3042\u308a\u7a4d\u6975\u7684\u306b\u4f7f\u7528\u3059\u308b\u6839\u62e0\u306f\u306a\u3044\u304c\u3001\u30a2\u30a6\u30c8\u30d6\u30ec\u30a4\u30af\u304c\u304a\u3053\u3063\u305f\u5834\u5408\u306b\u306f\u3001\u81e8\u5e8a\u6bd4\u8f03\u8a66\u9a13\u3092\u304a\u3053\u306a\u3046\u610f\u7fa9\u306f\u6b8b\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n <\/p>\n 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(New York City Board of Heath strain, Wyeth laboratories)\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u304c\u3001\u4e0a\u8a18\u306e\u526f\u4f5c\u7528\u306b\u52a0\u3048\u3066\u5fc3\u7b4b\u708e\u306e\u767a\u751f\u304c\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306fAnkara\u682a\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u308b\u3002\u6700\u8fd1\u3001\u5f37\u6bd2\u682a\uff08LO\uff09\u3068\u5f31\u6bd2\u682a(LC16m8)\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u3088\u308b\u75c5\u539f\u56e0\u5b50\u306e\u540c\u5b9a(B5R)\u304c\u884c\u308f\u308c\u305d\u306e\u5909\u7570\u30a6\u30a4\u30eb\u30b9\u306e\u4f5c\u6210\u304c\u958b\u767a\u4e2d\u3067\u3042\u308b\u3002\u65e5\u672c\u3067\u306f\u30012005\uff5e2010\u5e74\u306b\u56fd\u9023\u306e\u5e73\u548c\u7dad\u6301\u6d3b\u52d5\u306b\u5f93\u4e8b\u3059\u308b\u9678\u4e0a\u81ea\u885b\u968a\u54e1268\u4eba\u306b\u3001LC16m8 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\uff08 http:\/\/www.mhlw.go.jp\/kinkyu\/j-terr\/2004\/0514-1\/index.html<\/a>\uff09\u3092\u53c2\u7167\u3002<\/p>\n\u691c\u4f53\u3001\u83cc\u3001\u6c5a\u67d3\u5668\u6750\u7b49\u306e\u53d6\u308a\u6271\u3044<\/h5>\n\u5929\u7136\u75d8\u306fBSL-4\u306b\u5206\u985e\u3055\u308c\u308b\u306e\u3067\u3001\u611f\u67d3\u6027\u306e\u3042\u308b\u30a6\u30a4\u30eb\u30b9\u306e\u53d6\u308a\u6271\u3044\u306f\u56fd\u5185\u3067\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u3002\u8a3a\u65ad\u306e\u305f\u3081\u306e\u30a6\u30a4\u30eb\u30b9\u5b66\u7684\u691c\u67fb\u306f\u3001\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\uff08\u6751\u5c71\u5206\u5ba4\uff09\u30a6\u30a4\u30eb\u30b9\u7b2c\u4e00\u90e8\u5916\u6765\u6027\u30a6\u30a4\u30eb\u30b9\u5ba4\u306b\u304a\u3044\u3066\u53ef\u80fd\u3067\u3042\u308b\u3002<\/p>\n\n\u25b2TOP<\/p>\n\u53c2\u8003\u6587\u732e<\/h3>\n\nWorld Health Organization (WHO), Health topics, Smallpox, (http:\/\/www.who.int\/topics\/smallpox\/en\/<\/a>)<\/li>\nBreman JG, Henderson DA. Diagnosis and management of smallpox.N Engl J Med. 2002 Apr 25;346(17):1300-8.<\/li>\n\u5ca1\u90e8\u4fe1\u5f66, \u611f\u67d3\u75c7\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1a\u5929\u7136\u75d8, \u65e5\u533b\u96d1\u8a8c, 2001, 126, 1559-61.<\/li>\nCleri DJ, Porwancher RB, Ricketti AJ, et al. Smallpox as a bioterrorist weapon: myth or menace? Infect Dis Clin North Am. 2006, 20(2):329-57<\/li>\n\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u611f\u67d3\u75c7\u60c5\u5831\u30bb\u30f3\u30bf\u30fc, \u5929\u7136\u75d8 Smallpox, http:\/\/idsc.nih.go.jp\/disease\/smallpox\/index.html<\/a><\/li>\nNishiyama Y<\/a>, Fujii T<\/a>, Kanatani Y<\/a>, Shinmura Y<\/a>, Yokote H<\/a>, Hashizume S<\/a>. Freeze-dried live attenuated smallpox vaccine prepared in cell culture\u201cLC16-KAKETSUKEN\u201d: Post-marketing surveillance study on safety and efficacy compliant with Good Clinical Practice. Vaccine 2015. 33. 6120\u20136127.<\/li>\n<\/ol>\n\u25b2TOP<\/a>\n2018\u5e743\u6708 \u6539\u8a02<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"\u75c5\u539f\u4f53\u306e\u7279\u5fb4 \u5929\u7136\u75d8\u306e\u75c5\u539f\u4f53\u306f\u3001\u5929\u7136\u75d8\uff08\u75d8\u7621\uff09\u30a6\u30a4\u30eb\u30b9\uff08Variola virus\uff09\u3067\u3042\u308a\u3001\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u79d1\uff08Poxviridae\uff09\u306e\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u5c5e\uff08Genus Orthopox\uff09\u306b\u5206\u985e\u3055\u308c\u308b\u3002\u725b\u75d8\u30a6\u30a4\u30eb\u30b9\u3001\u30ef\u30af\u30b7\u30cb\u2026 \u7d9a\u304d\u3092\u8aad\u3080 »<\/a><\/span><\/p>\n","protected":false},"author":12,"featured_media":0,"parent":100,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/139"}],"collection":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/comments?post=139"}],"version-history":[{"count":17,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/139\/revisions"}],"predecessor-version":[{"id":1394,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/139\/revisions\/1394"}],"up":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/100"}],"wp:attachment":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/media?parent=139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}](\"\/\/h-crisis.niph.go.jp\/bt\/wp-content\/uploads\/sites\/3\/2016\/04\/img_20090217091645.jpg\"){kind=link}
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![\u56f34<\/a> 3-1\uff09\u3002\u5857\u62b9\u6a19\u672c\u306f\u30a6\u30a4\u30eb\u30b9\u304c\u4e0d\u6d3b\u5316\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u3067\u30b9\u30e9\u30a4\u30c9\u30b0\u30e9\u30b9\u30b1\u30fc\u30b9(\u30d7\u30e9\u30b9\u30c6\u30a3\u30c3\u30af\u88fd\u306e25\u679a\u7a0b\u5ea6\u5165\u308b\u3082\u306e)\u306b\u5165\u308c\u30c6\u30fc\u30d7\u7b49\u3067\u5bc6\u9589\u3057\u3001\u3055\u3089\u306b\u30d3\u30cb\u30fc\u30eb\u888b\u7b49\u306b\u5165\u308c\u3066\u30c6\u30fc\u30d4\u30f3\u30b0\u3059\u308b\u3002\u51b7\u5374\u72b6\u614b\u3092\u4fdd\u3063\u3066\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u3078\u904b\u3076\u3002\u51cd\u7d50\u306f\u4e0d\u53ef\u3002<\/li>\n\u6c34\u75b1\u6db2\u30fb\u81bf\u75b1\u6db2\uff1a\nPBS\u30920.1\u301c0.2ml\u5165\u308c\u305f\u6ce8\u5c04\u91dd(26\uff27)\u4ed8\u304d\u306e1ml\u306e\u6ce8\u5c04\u5668\uff08\u30c4\u30d9\u30eb\u30af\u30ea\u30f3\u7528\uff09\u3092\u75b1\u819c\u304b\u3089\u633f\u5165\u3057\u3066\u30012\u301c3\u56de\u30dd\u30f3\u30d4\u30f3\u30b0\u3057\u3066\u5185\u5bb9\u6db2\u3092\u63a1\u53d6\u3059\u308b\uff08\u56f34<\/a> 3-2\uff09\u3002\u30bb\u30e9\u30e0\u30c1\u30e5\u30fc\u30d6\u7b49\u306b\u5185\u5bb9\u6db2\u3092\u5165\u308c\u3066\u30014\u2103\u306b\u51b7\u5374\u3057\u3066\u611f\u67d3\u7814\u3078\u904b\u3076\u3002<\/li>\n\u75c2\u76ae\uff1a\n\u30d4\u30f3\u30bb\u30c3\u30c8\u3067\u75c2\u76ae\u3092\u63a1\u53d6\u3057\uff08\u56f34<\/a> 3-3\uff09\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u30c1\u30e5\u30fc\u30d6\u7b49\u306b\u5165\u308c\u3066\u5bc6\u6813\u3057\u30014\u00baC\u306b\u51b7\u5374\u3057\u3066\u611f\u67d3\u7814\u3078\u904b\u3076\u3002<\/li>\n\u8840\u6e05\uff1a\n\u5b89\u5168\u30ad\u30e3\u30d3\u30cd\u30c3\u30c8\u7b49\u306e\u8a2d\u5099\u304c\u7121\u3044\u5834\u5408\u3001\u51dd\u56fa\u8840\u6db2\u3092\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u306b\u904b\u3076\u3002\u53ef\u80fd\u306a\u5834\u5408\u306f\u5e38\u6cd5\u306b\u3088\u308b\u3002\u305f\u3060\u3057\u3001\u8840\u6db2\u51dd\u56fa\u584a\u3001\u8840\u6db2\u4e2d\u306b\u30a6\u30a4\u30eb\u30b9\u304c\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u8840\u6e05\u5206\u96e2\u7b49\u306b\u7528\u3044\u305f\u8a66\u9a13\u7ba1\u3001\u30d4\u30da\u30c3\u30c8\u3001\u8840\u6db2\u51dd\u56fa\u584a\u7b49\u306f\u5fc5\u305a\u30aa\u30fc\u30c8\u30af\u30ec\u30fc\u30d6\u51e6\u7406\u3059\u308b\u3002\u8840\u6e05\u306f\u3001\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u3078\u904b\u3076\u3002<\/li>\n\u691c\u4f53\u306e\u5305\u88c5\u7b49\uff1a\n\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u306e\u300c\u611f\u67d3\u6027\u6750\u6599\uff08\u75c5\u539f\u4f53\u7b49\u53ca\u3073\u8a3a\u65ad\u7528\u306e\u30d2\u30c8\u3042\u308b\u3044\u306f\u52d5\u7269\u306e\u691c\u4f53\uff09\u306e\u8f38\u9001\u306b\u95a2\u3059\u308b\u30de\u30cb\u30e5\u30a2\u30eb\uff08\u6301\u53c2\u306e\u5834\u5408\uff09\u300d\uff08\u554f\u3044\u5408\u308f\u305b\u5148\uff1a\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240 \u696d\u52d9\u8ab2 TEL: 03-5285-1111\uff09\u306b\u5f93\u3063\u3066\u3001\u57fa\u672c\u578b\u4e09\u91cd\u5305\u88c5\u5bb9\u5668\u306b\u691c\u4f53\u3092\u5165\u308c\u308b\uff08\u300c\u30a6\u30a4\u30eb\u30b9\u6027\u51fa\u8840\u71b1\u300d\u306e\u9805\u53c2\u7167\uff09\u3002\u691c\u4f53\u306f\u3001\u5fc5\u305a\u6301\u53c2\u3059\u308b\u3002<\/li>\n<\/ol>\n\u5fae\u751f\u7269\u5b66\u7684\u691c\u67fb\u6cd5<\/h4>\n\n\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u9023\u9396\u53cd\u5fdc (PCR)\uff1a\nPCR\u6cd5\u3067\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u306e\u691c\u51fa\u3092\u884c\u3046\u3002<\/li>\n\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u691c\u51fa\u86cd\u5149\u6297\u4f53\u6cd5\uff1a\n\u5857\u62b9\u6a19\u672c\u3092\u30a2\u30bb\u30c8\u30f3\u3067\u5ba4\u6e2910\u5206\u9593\u56fa\u5b9a\u3057\u305f\u3082\u306e\u3092\u7528\u3044\u308b\u3002\u6297\u30ef\u30af\u30c1\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u30a6\u30b5\u30ae\u8840\u6e05\u3092\uff11\u6b21\u8840\u6e05\u3068\u3057\u3066\u3001FITC\u6a19\u8b58\u6297\u30a6\u30b5\u30aeIgG\u6297\u4f53\u3092\uff12\u6b21\u8840\u6e05\u306b\u7528\u3044\u3066\u9593\u63a5\u86cd\u5149\u6297\u4f53\u6cd5\u3092\u884c\u3046\u3002\u3053\u306e\u65b9\u6cd5\u3067\u306f\u3001\u691c\u4f53\uff08\u5857\u62b9\u6a19\u672c\uff09\u306b\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u306e\u5b58\u5728\u3092\u78ba\u5b9a\u3067\u304d\u308b\u304c\uff08\u56f35<\/a>\uff09\u3001\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u3068\u305d\u306e\u4ed6\u306e\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u306e\u9451\u5225\u306f\u3067\u304d\u306a\u3044\u3002\uff11\u6b21\u8840\u6e05\u306b\u6297VZV\uff08\u6c34\u75d8\u30a6\u30a4\u30eb\u30b9\uff09\u6297\u4f53\u3092\u7528\u3044\u308b\u3068\u6c34\u75d8\u3068\u306e\u9451\u5225\u306f\u3067\u304d\u308b\u3002<\/li>\n\u96fb\u5b50\u9855\u5fae\u93e1\u306b\u3088\u308b\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u306e\u691c\u51fa\u30fb\u540c\u5b9a\uff08\u56f36<\/a>\uff09\uff1a<\/li>\n<\/ol>\n\u691c\u4f53\uff08\u6c34\u75b1\u6db2\u3001\u81bf\u75b1\u6db2\u3001\u75c2\u76ae\u4e73\u5264\uff09\u3092\u5bfe\u8c61\u306b\u30ea\u30f3\u30bf\u30f3\u30b0\u30b9\u30c6\u30f3\u9178\u306b\u3088\u308b\u30cd\u30ac\u30c6\u30a3\u30d6\u67d3\u8272\u5f8c\u306b\u96fb\u5b50\u9855\u5fae\u93e1\u89b3\u5bdf\u3057\u3066\u3001\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u306e\u691c\u51fa\u3092\u884c\u3046\u3002\u3053\u306e\u691c\u67fb\u3067\u306f\u3001\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u3068\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u3001\u30ef\u30af\u30c1\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u7b49\u306e\u4ed6\u306e\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u3068\u306f\u9451\u5225\u3067\u304d\u306a\u3044\u3002\u6c34\u75d8\u60a3\u8005\u691c\u4f53\u306b\u307f\u3089\u308c\u308b\u6c34\u75d8\u30a6\u30a4\u30eb\u30b9\uff08\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\uff09\u3068\u306f\u5bb9\u6613\u306b\u8b58\u5225\u3067\u304d\u308b\u3002<\/p>\n\u8a3a\u65ad\u57fa\u6e96\uff1a<\/h5>\n\u4e0a\u8a18\u306e\u5b9f\u9a13\u5ba4\u8a3a\u65ad\u6cd5\u306b\u3088\u308b\u691c\u67fb\u3067\u3001\u4ee5\u4e0b\u306e\u3044\u305a\u308c\u304b\u304c\u6e80\u305f\u3055\u308c\u305f\u5834\u5408\u3001\u5929\u7136\u75d8\u3068\u3059\u308b\u3002<\/p>\n\n\u88ab\u9a13\u691c\u4f53\u304b\u3089\u300c\u8a3a\u65ad\u306e\u305f\u3081\u306e\u57f9\u990a\u300d\u3067\u75d8\u305d\u3046\u30a6\u30a4\u30eb\u30b9\u304c\u540c\u5b9a\u3055\u308c\u305f\uff08\u3053\u306e\u691c\u67fb\u306b\u306fBSL4\u5b9f\u9a13\u5ba4\u306e\u7a3c\u50cd\u304c\u5fc5\u8981\uff09\u3002<\/li>\n\u88ab\u9a13\u691c\u4f53\u304b\u3089\u300cPCR\u6cd5\u300d\u3067\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u304c\u691c\u51fa\u3055\u308c\u305f\u3002<\/li>\n<\/ul>\n\u307e\u305f\u3001\u6b21\u306e\u5834\u5408\u306f\u300c\u5929\u7136\u75d8\u300d\u3092\u7591\u3046\u3002<\/p>\n\n\u88ab\u9a13\u691c\u4f53\u304b\u3089\u300c\u96fb\u5b50\u9855\u5fae\u93e1\u89b3\u5bdf\u300d\u3067\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u304c\u691c\u51fa\u3055\u308c\u305f\u3002<\/li>\n\u88ab\u9a13\u691c\u4f53\u304b\u3089\u300c\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u691c\u51fa\u86cd\u5149\u6297\u4f53\u6cd5\u300d\u3067\uff0c\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u86cb\u767d\u304c\u691c\u51fa\u3055\u308c\u305f\u3002<\/li>\n<\/ul>\n\u25b2TOP<\/a><\/p>\n\u6cbb\u7642<\/h3>\n\u85ac\u7269\u7642\u6cd5\uff08\u6297\u83cc\u85ac\u7642\u6cd5\uff09<\/h4>\n\u30a6\u30a4\u30eb\u30b9\u66dd\u9732\u5f8c4\u65e5\u76ee\u4ee5\u5185\u3067\u3042\u308c\u3070\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306b\u3088\u308a\u8efd\u75c7\u5316\u307e\u305f\u306f\u767a\u75c5\u4e88\u9632\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u3002\u307e\u305f\u3001\u66dd\u9732\u5f8c1\u9031\u9593\u4ee5\u5185\u3067\u3042\u308c\u3070\u3001\u3042\u308b\u7a0b\u5ea6\u306e\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3053\u3068\u304c\u7d4c\u9a13\u7684\u306b\u77e5\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u66dd\u9732\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u5b9f\u3067\u3042\u308b\u5834\u5408\u306b\u306f\u3001\u767a\u75c7\u524d\u3067\u3042\u308c\u3070\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u8a66\u307f\u308b\u4fa1\u5024\u306f\u3042\u308b\u3068\u601d\u308f\u308c\u308b\u3002<\/p>\n\u9577\u304f\u3001\u7279\u7570\u7684\u306a\u6cbb\u7642\u85ac\u306f\u306a\u304f\u3001\u767a\u75c7\u5f8c\u306e\u6cbb\u7642\u306f\u5bfe\u8c61\u7642\u6cd5\u304c\u4e2d\u5fc3\u3068\u306a\u3063\u3066\u3044\u305f\u304c\u3001\u7c73\u56fd\u3067\u306f2018\u5e74\u306bTpoxx (\u30c6\u30b3\u30d3\u30ea\u30de\u30c3\u30c8 : Tecovirimat)\u30012021\u5e74\u306b\u30d6\u30ea\u30f3\u30b7\u30c9\u30d5\u30a9\u30d3\u30eb(Brincidofovir:BCV, Chimerix Inc.)\u304cFDA\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u65e5\u672c\u56fd\u5185\u306e\u627f\u8a8d\u85ac\u306f\u306a\u3044\u304c\u3001\u5b9f\u969b\u306b\u672c\u75be\u60a3\u306b\u906d\u9047\u3059\u308b\u3053\u3068\u306b\u306a\u3063\u305f\u5834\u5408\u306f\u3001\u305d\u306e\u6642\u70b9\u3067\u306e\u6d77\u5916\u306e\u627f\u8a8d\u85ac\u306e\u56fd\u5185\u3067\u306e\u5165\u624b\u72b6\u6cc1\u3092\u8abf\u3079\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u91cd\u75c7\u4f8b\u306b\u304a\u3044\u3066\u306f\u3001\u65e9\u671f\u306b\u306f\u93ae\u75db\u5264\u6295\u4e0e\u3001\u6c34\u5206\u88dc\u7d66\u3001\u6804\u990a\u88dc\u7d66\u53ca\u3073\u6c17\u9053\u78ba\u4fdd\uff08\u4e0a\u6c17\u9053\u6d6e\u816b\u306b\u3088\u308b\u6c17\u9053\u9589\u585e\u306e\u304a\u305d\u308c\u304c\u3042\u308b\u5834\u5408\u306f\u30d2\u30c9\u30ed\u30b3\u30eb\u30c1\u30be\u30f3\u3092\u6295\u4e0e\uff09\u3001\u767a\u75b9\u671f\u306b\u306f\u76ae\u819a\u306e\u885b\u751f\u4fdd\u6301\u3001\u767a\u75b9\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u3092\u304a\u3053\u306a\u3046\u3002\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u30b7\u30c9\u30d5\u30a9\u30d3\u30eb\u306e\u81e8\u5e8a\u7684\u306a\u6709\u7528\u6027\u3092\u793a\u3059\u30c7\u30fc\u30bf\u306f\u306a\u3044\u304c\u3001in vitro\u3084\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u306f\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u306b\u6d3b\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001BCV\u306f\u30b7\u30c9\u30d5\u30a9\u30d3\u30eb\u306e\u8102\u8cea\u7d50\u5408\u4f53\u3067\u3042\u308b\u3002\u814e\u969c\u5bb3\u3084\u597d\u4e2d\u7403\u6e1b\u5c11\u306a\u3069\u306e\u526f\u4f5c\u7528\u3082\u3042\u308a\u7a4d\u6975\u7684\u306b\u4f7f\u7528\u3059\u308b\u6839\u62e0\u306f\u306a\u3044\u304c\u3001\u30a2\u30a6\u30c8\u30d6\u30ec\u30a4\u30af\u304c\u304a\u3053\u3063\u305f\u5834\u5408\u306b\u306f\u3001\u81e8\u5e8a\u6bd4\u8f03\u8a66\u9a13\u3092\u304a\u3053\u306a\u3046\u610f\u7fa9\u306f\u6b8b\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n <\/p>\n <\/p>\n\u305d\u306e\u4ed6\u6cbb\u7642\u4e0a\u306e\u7559\u610f\u70b9<\/h4>\n\u6b7b\u4ea1\u306f\u4e3b\u306b\u30a6\u30a4\u30eb\u30b9\u8840\u75c7\u306b\u3088\u308b\u3082\u306e\u3067\u30011\u9031\u76ee\u5f8c\u534a\u304b\u30892\u9031\u76ee\u306b\u304b\u3051\u3066\u306e\u6642\u671f\u304c\u591a\u3044\u305f\u3081\u3001\u7279\u306b\u91cd\u75c7\u4f8b\u3067\u306f\u5168\u8eab\u7ba1\u7406\u3092\u542b\u3081\u305f\u96c6\u4e2d\u6cbb\u7642\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u76ae\u819a\u306e\u885b\u751f\u72b6\u614b\u306e\u7dad\u6301\u306f\u4e8c\u6b21\u611f\u67d3\u306e\u4e88\u9632\u306b\u91cd\u8981\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u7834\u88c2\u3057\u305f\u5c0f\u6c34\u75b1\u53ca\u3073\u81bf\u75b1\u3001\u76ae\u306e\u3080\u3051\u305f\u90e8\u4f4d\u306e\u7d30\u83cc\u4e8c\u6b21\u611f\u67d3\u3092\u5b8c\u5168\u306b\u4e88\u9632\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002\u76ae\u819a\u3084\u5c3f\u8def\u3001\u6c17\u9053\u306a\u3069\u306e\u4e8c\u6b21\u611f\u67d3\u306b\u5bfe\u3057\u3066\u6297\u83cc\u85ac\u3092\u6295\u4e0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u5f97\u308b\u3002<\/p>\n\u25b2TOP<\/a><\/p>\n\u4e88\u9632\uff08\u30ef\u30af\u30c1\u30f3\uff09<\/h3>\n\u30ef\u30af\u30c1\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u3092\u7528\u3044\u305f\u5f31\u6bd2\u751f\u30a6\u30a3\u30eb\u30b9\u30ef\u30af\u30c1\u30f3\u304c\u3042\u308b\u3002\u65e5\u672c\u3067\u306f\u30a6\u30b5\u30ae\u814e\u7d30\u80de\u3067\u5897\u6b96\u3057\u305f\u795e\u7d4c\u75c5\u539f\u6027\u3092\u6b20\u304f\u30ea\u30b9\u30bf\u30fc\u682a\u306e\u6539\u826f\u578bLC16m8\u682a\u3092\u4f7f\u7528\u3059\u308b\u3002\uff11\u56de\u306e\u63a5\u7a2e\u3067\uff13\u5e74\u304b\u3089\uff15\u5e74\u306e\u9632\u5fa1\u514d\u75ab\u304c\u3048\u3089\u308c\u308b\u3002\u611f\u67d3\u6570\u65e5\u4ee5\u5185\u306a\u3089\u3070\u6cbb\u7642\u7684\u306b\u4f7f\u7528\u3057\u3066\u3082\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u308b\u3002\u526f\u4f5c\u7528\u306f\u30ea\u30b9\u30bf\u30fc\u682a\u3067\uff11\uff10\uff10\u4e07\u4eba\u306b\uff12\uff10\u4eba\u306b\u8133\u708e\u304c\u767a\u751f\u3057\u3001\u305d\u306e\uff15\uff10\uff05\u304c\u6b7b\u4ea1\u3059\u308b\u3002\u4ed6\u306b\u5168\u8eab\u6027\u7a2e\u75d8\u75b9\u3001\u6e7f\u75b9\u6027\u7a2e\u75d8\u3001\u63a5\u89e6\u6027\u7a2e\u75d8\u306a\u3069\u306e\u526f\u4f5c\u7528\u304c\u3042\u308b\u3002\u975e\u7dca\u6025\u6642\u306b\u304a\u3044\u3066\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u65e2\u5f80\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3042\u308b\u3044\u306f\u6e7f\u75b9\u60a3\u8005\u304a\u3088\u3073\u305d\u306e\u540c\u5c45\u5bb6\u65cf\u3001HIV\u967d\u6027\u3001\u514d\u75ab\u6291\u5236\u5264\u670d\u7528\u3001\u598a\u5a66\u3001\uff11\uff12\u30f5\u6708\u672a\u6e80\u306e\u4e73\u5150\u306b\u306f\u7981\u5fcc\u3067\u3042\u308b\u3002\u3000\u7c73\u56fd\u3067\u306fDryvax (New York City Board of Heath strain, Wyeth laboratories)\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u304c\u3001\u4e0a\u8a18\u306e\u526f\u4f5c\u7528\u306b\u52a0\u3048\u3066\u5fc3\u7b4b\u708e\u306e\u767a\u751f\u304c\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306fAnkara\u682a\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u308b\u3002\u6700\u8fd1\u3001\u5f37\u6bd2\u682a\uff08LO\uff09\u3068\u5f31\u6bd2\u682a(LC16m8)\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u3088\u308b\u75c5\u539f\u56e0\u5b50\u306e\u540c\u5b9a(B5R)\u304c\u884c\u308f\u308c\u305d\u306e\u5909\u7570\u30a6\u30a4\u30eb\u30b9\u306e\u4f5c\u6210\u304c\u958b\u767a\u4e2d\u3067\u3042\u308b\u3002\u65e5\u672c\u3067\u306f\u30012005\uff5e2010\u5e74\u306b\u56fd\u9023\u306e\u5e73\u548c\u7dad\u6301\u6d3b\u52d5\u306b\u5f93\u4e8b\u3059\u308b\u9678\u4e0a\u81ea\u885b\u968a\u54e1268\u4eba\u306b\u3001LC16m8 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\u4eba\uff080.4%\uff09\u3067\u3042\u3063\u305f\u3002\n\u6ce8\uff09\u5584\u611f\uff1a\u7a2e\u75d8\u63a5\u7a2e\u306e\u8de1\u304c\u306f\u3063\u304d\u308a\u3068\u3064\u3044\u3066\u514d\u75ab\u304c\u7372\u5f97\u3055\u308c\u305f\u3053\u3068\u3092\u8a00\u3046\u3002\u306a\u304a\u3001\u63a5\u7a2e\u306e\u8de1\u304c\u4e0d\u660e\u306a\u5834\u5408\u306f\u514d\u75ab\u304c\u7372\u5f97\u3055\u308c\u3066\u3044\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u308c\u3092\u300c\u4e0d\u5584\u611f\u300d\u3068\u8a00\u3046\u3002<\/p>\n\u25b2TOP<\/a><\/div>\n\u30d0\u30a4\u30aa\u30cf\u30b6\u30fc\u30c9\u5bfe\u7b56<\/h3>\n\u60a3\u8005\u306e\u9694\u96e2<\/h5>\n\u5929\u7136\u75d8\u306f\u98db\u6cab\u611f\u67d3\u3092\u4e2d\u5fc3\u3068\u3057\u3066\u63a5\u89e6\u611f\u67d3\u3084\u7a7a\u6c17\u611f\u67d3\u3082\u304a\u3053\u308a\u3046\u308b\u3002\u75c2\u76ae\u306e\u4e0b\u306b\u6700\u5f8c\u307e\u3067\u30a6\u30a4\u30eb\u30b9\u304c\u6b8b\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u75c2\u76ae\u304c\u5b8c\u5168\u306b\u843d\u5c51\u3059\u308b\u307e\u3067\u9694\u96e2\u6cbb\u7642\u3059\u308b\u3002\u8a3a\u7642\u306f\u3001\u30c7\u30a3\u30b9\u30dd\u30fc\u30b6\u30d6\u30eb\u306e\u30ac\u30a6\u30f3\u3001\u624b\u888b\u3001\u9774\u30ab\u30d0\u30fc\u3001\u30d8\u30c3\u30c9\u30ab\u30d0\u30fc\u3001\u30b4\u30fc\u30b0\u30eb\u3001N95\u30de\u30b9\u30af\u3092\u542b\u3080\u9632\u8b77\u670d\u3092\u7740\u7528\u3057\u3001\u4e88\u9632\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u8077\u54e1\u304c\u5b9f\u65bd\u3059\u308b\u3002<\/p>\n\u533b\u7642\u4f53\u5236\u3084\u60a3\u8005\u79fb\u9001\u306e\u8a73\u7d30\u306b\u95a2\u3057\u3066\u306f\u3001\u539a\u751f\u52b4\u50cd\u7701\u306e\u300c\u5929\u7136\u75d8\u5bfe\u7b56\u6307\u91dd\uff08\u7b2c5\u7248\uff09\u300d \uff08 http:\/\/www.mhlw.go.jp\/kinkyu\/j-terr\/2004\/0514-1\/index.html<\/a>\uff09\u3092\u53c2\u7167\u3002<\/p>\n\u691c\u4f53\u3001\u83cc\u3001\u6c5a\u67d3\u5668\u6750\u7b49\u306e\u53d6\u308a\u6271\u3044<\/h5>\n\u5929\u7136\u75d8\u306fBSL-4\u306b\u5206\u985e\u3055\u308c\u308b\u306e\u3067\u3001\u611f\u67d3\u6027\u306e\u3042\u308b\u30a6\u30a4\u30eb\u30b9\u306e\u53d6\u308a\u6271\u3044\u306f\u56fd\u5185\u3067\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u3002\u8a3a\u65ad\u306e\u305f\u3081\u306e\u30a6\u30a4\u30eb\u30b9\u5b66\u7684\u691c\u67fb\u306f\u3001\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\uff08\u6751\u5c71\u5206\u5ba4\uff09\u30a6\u30a4\u30eb\u30b9\u7b2c\u4e00\u90e8\u5916\u6765\u6027\u30a6\u30a4\u30eb\u30b9\u5ba4\u306b\u304a\u3044\u3066\u53ef\u80fd\u3067\u3042\u308b\u3002<\/p>\n\n\u25b2TOP<\/p>\n\u53c2\u8003\u6587\u732e<\/h3>\n\nWorld Health Organization (WHO), Health topics, Smallpox, (http:\/\/www.who.int\/topics\/smallpox\/en\/<\/a>)<\/li>\nBreman JG, Henderson DA. Diagnosis and management of smallpox.N Engl J Med. 2002 Apr 25;346(17):1300-8.<\/li>\n\u5ca1\u90e8\u4fe1\u5f66, \u611f\u67d3\u75c7\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1a\u5929\u7136\u75d8, \u65e5\u533b\u96d1\u8a8c, 2001, 126, 1559-61.<\/li>\nCleri DJ, Porwancher RB, Ricketti AJ, et al. Smallpox as a bioterrorist weapon: myth or menace? Infect Dis Clin North Am. 2006, 20(2):329-57<\/li>\n\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u611f\u67d3\u75c7\u60c5\u5831\u30bb\u30f3\u30bf\u30fc, \u5929\u7136\u75d8 Smallpox, http:\/\/idsc.nih.go.jp\/disease\/smallpox\/index.html<\/a><\/li>\nNishiyama Y<\/a>, Fujii T<\/a>, Kanatani Y<\/a>, Shinmura Y<\/a>, Yokote H<\/a>, Hashizume S<\/a>. Freeze-dried live attenuated smallpox vaccine prepared in cell culture\u201cLC16-KAKETSUKEN\u201d: Post-marketing surveillance study on safety and efficacy compliant with Good Clinical Practice. Vaccine 2015. 33. 6120\u20136127.<\/li>\n<\/ol>\n\u25b2TOP<\/a>\n2018\u5e743\u6708 \u6539\u8a02<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"\u75c5\u539f\u4f53\u306e\u7279\u5fb4 \u5929\u7136\u75d8\u306e\u75c5\u539f\u4f53\u306f\u3001\u5929\u7136\u75d8\uff08\u75d8\u7621\uff09\u30a6\u30a4\u30eb\u30b9\uff08Variola virus\uff09\u3067\u3042\u308a\u3001\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u79d1\uff08Poxviridae\uff09\u306e\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u5c5e\uff08Genus Orthopox\uff09\u306b\u5206\u985e\u3055\u308c\u308b\u3002\u725b\u75d8\u30a6\u30a4\u30eb\u30b9\u3001\u30ef\u30af\u30b7\u30cb\u2026 \u7d9a\u304d\u3092\u8aad\u3080 »<\/a><\/span><\/p>\n","protected":false},"author":12,"featured_media":0,"parent":100,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/139"}],"collection":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/comments?post=139"}],"version-history":[{"count":17,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/139\/revisions"}],"predecessor-version":[{"id":1394,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/139\/revisions\/1394"}],"up":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/100"}],"wp:attachment":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/media?parent=139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}](\"\/\/h-crisis.niph.go.jp\/bt\/wp-content\/uploads\/sites\/3\/2016\/04\/img_20090217094920.jpg\"){kind=link}
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Inc.)\u304cFDA\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u65e5\u672c\u56fd\u5185\u306e\u627f\u8a8d\u85ac\u306f\u306a\u3044\u304c\u3001\u5b9f\u969b\u306b\u672c\u75be\u60a3\u306b\u906d\u9047\u3059\u308b\u3053\u3068\u306b\u306a\u3063\u305f\u5834\u5408\u306f\u3001\u305d\u306e\u6642\u70b9\u3067\u306e\u6d77\u5916\u306e\u627f\u8a8d\u85ac\u306e\u56fd\u5185\u3067\u306e\u5165\u624b\u72b6\u6cc1\u3092\u8abf\u3079\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u91cd\u75c7\u4f8b\u306b\u304a\u3044\u3066\u306f\u3001\u65e9\u671f\u306b\u306f\u93ae\u75db\u5264\u6295\u4e0e\u3001\u6c34\u5206\u88dc\u7d66\u3001\u6804\u990a\u88dc\u7d66\u53ca\u3073\u6c17\u9053\u78ba\u4fdd\uff08\u4e0a\u6c17\u9053\u6d6e\u816b\u306b\u3088\u308b\u6c17\u9053\u9589\u585e\u306e\u304a\u305d\u308c\u304c\u3042\u308b\u5834\u5408\u306f\u30d2\u30c9\u30ed\u30b3\u30eb\u30c1\u30be\u30f3\u3092\u6295\u4e0e\uff09\u3001\u767a\u75b9\u671f\u306b\u306f\u76ae\u819a\u306e\u885b\u751f\u4fdd\u6301\u3001\u767a\u75b9\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u3092\u304a\u3053\u306a\u3046\u3002\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u30b7\u30c9\u30d5\u30a9\u30d3\u30eb\u306e\u81e8\u5e8a\u7684\u306a\u6709\u7528\u6027\u3092\u793a\u3059\u30c7\u30fc\u30bf\u306f\u306a\u3044\u304c\u3001in 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(New York City Board of Heath strain, Wyeth laboratories)\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u304c\u3001\u4e0a\u8a18\u306e\u526f\u4f5c\u7528\u306b\u52a0\u3048\u3066\u5fc3\u7b4b\u708e\u306e\u767a\u751f\u304c\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306fAnkara\u682a\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u308b\u3002\u6700\u8fd1\u3001\u5f37\u6bd2\u682a\uff08LO\uff09\u3068\u5f31\u6bd2\u682a(LC16m8)\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u3088\u308b\u75c5\u539f\u56e0\u5b50\u306e\u540c\u5b9a(B5R)\u304c\u884c\u308f\u308c\u305d\u306e\u5909\u7570\u30a6\u30a4\u30eb\u30b9\u306e\u4f5c\u6210\u304c\u958b\u767a\u4e2d\u3067\u3042\u308b\u3002\u65e5\u672c\u3067\u306f\u30012005\uff5e2010\u5e74\u306b\u56fd\u9023\u306e\u5e73\u548c\u7dad\u6301\u6d3b\u52d5\u306b\u5f93\u4e8b\u3059\u308b\u9678\u4e0a\u81ea\u885b\u968a\u54e1268\u4eba\u306b\u3001LC16m8 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\u4eba\uff080.4%\uff09\u3067\u3042\u3063\u305f\u3002\n\u6ce8\uff09\u5584\u611f\uff1a\u7a2e\u75d8\u63a5\u7a2e\u306e\u8de1\u304c\u306f\u3063\u304d\u308a\u3068\u3064\u3044\u3066\u514d\u75ab\u304c\u7372\u5f97\u3055\u308c\u305f\u3053\u3068\u3092\u8a00\u3046\u3002\u306a\u304a\u3001\u63a5\u7a2e\u306e\u8de1\u304c\u4e0d\u660e\u306a\u5834\u5408\u306f\u514d\u75ab\u304c\u7372\u5f97\u3055\u308c\u3066\u3044\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u308c\u3092\u300c\u4e0d\u5584\u611f\u300d\u3068\u8a00\u3046\u3002<\/p>\n\u25b2TOP<\/a><\/div>\n\u30d0\u30a4\u30aa\u30cf\u30b6\u30fc\u30c9\u5bfe\u7b56<\/h3>\n\u60a3\u8005\u306e\u9694\u96e2<\/h5>\n\u5929\u7136\u75d8\u306f\u98db\u6cab\u611f\u67d3\u3092\u4e2d\u5fc3\u3068\u3057\u3066\u63a5\u89e6\u611f\u67d3\u3084\u7a7a\u6c17\u611f\u67d3\u3082\u304a\u3053\u308a\u3046\u308b\u3002\u75c2\u76ae\u306e\u4e0b\u306b\u6700\u5f8c\u307e\u3067\u30a6\u30a4\u30eb\u30b9\u304c\u6b8b\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u75c2\u76ae\u304c\u5b8c\u5168\u306b\u843d\u5c51\u3059\u308b\u307e\u3067\u9694\u96e2\u6cbb\u7642\u3059\u308b\u3002\u8a3a\u7642\u306f\u3001\u30c7\u30a3\u30b9\u30dd\u30fc\u30b6\u30d6\u30eb\u306e\u30ac\u30a6\u30f3\u3001\u624b\u888b\u3001\u9774\u30ab\u30d0\u30fc\u3001\u30d8\u30c3\u30c9\u30ab\u30d0\u30fc\u3001\u30b4\u30fc\u30b0\u30eb\u3001N95\u30de\u30b9\u30af\u3092\u542b\u3080\u9632\u8b77\u670d\u3092\u7740\u7528\u3057\u3001\u4e88\u9632\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u8077\u54e1\u304c\u5b9f\u65bd\u3059\u308b\u3002<\/p>\n\u533b\u7642\u4f53\u5236\u3084\u60a3\u8005\u79fb\u9001\u306e\u8a73\u7d30\u306b\u95a2\u3057\u3066\u306f\u3001\u539a\u751f\u52b4\u50cd\u7701\u306e\u300c\u5929\u7136\u75d8\u5bfe\u7b56\u6307\u91dd\uff08\u7b2c5\u7248\uff09\u300d \uff08 http:\/\/www.mhlw.go.jp\/kinkyu\/j-terr\/2004\/0514-1\/index.html<\/a>\uff09\u3092\u53c2\u7167\u3002<\/p>\n\u691c\u4f53\u3001\u83cc\u3001\u6c5a\u67d3\u5668\u6750\u7b49\u306e\u53d6\u308a\u6271\u3044<\/h5>\n\u5929\u7136\u75d8\u306fBSL-4\u306b\u5206\u985e\u3055\u308c\u308b\u306e\u3067\u3001\u611f\u67d3\u6027\u306e\u3042\u308b\u30a6\u30a4\u30eb\u30b9\u306e\u53d6\u308a\u6271\u3044\u306f\u56fd\u5185\u3067\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u3002\u8a3a\u65ad\u306e\u305f\u3081\u306e\u30a6\u30a4\u30eb\u30b9\u5b66\u7684\u691c\u67fb\u306f\u3001\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\uff08\u6751\u5c71\u5206\u5ba4\uff09\u30a6\u30a4\u30eb\u30b9\u7b2c\u4e00\u90e8\u5916\u6765\u6027\u30a6\u30a4\u30eb\u30b9\u5ba4\u306b\u304a\u3044\u3066\u53ef\u80fd\u3067\u3042\u308b\u3002<\/p>\n\n\u25b2TOP<\/p>\n\u53c2\u8003\u6587\u732e<\/h3>\n\nWorld Health Organization (WHO), Health topics, Smallpox, (http:\/\/www.who.int\/topics\/smallpox\/en\/<\/a>)<\/li>\nBreman JG, Henderson DA. Diagnosis and management of smallpox.N Engl J Med. 2002 Apr 25;346(17):1300-8.<\/li>\n\u5ca1\u90e8\u4fe1\u5f66, \u611f\u67d3\u75c7\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1a\u5929\u7136\u75d8, \u65e5\u533b\u96d1\u8a8c, 2001, 126, 1559-61.<\/li>\nCleri DJ, Porwancher RB, Ricketti AJ, et al. Smallpox as a bioterrorist weapon: myth or menace? Infect Dis Clin North Am. 2006, 20(2):329-57<\/li>\n\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u611f\u67d3\u75c7\u60c5\u5831\u30bb\u30f3\u30bf\u30fc, \u5929\u7136\u75d8 Smallpox, http:\/\/idsc.nih.go.jp\/disease\/smallpox\/index.html<\/a><\/li>\nNishiyama Y<\/a>, Fujii T<\/a>, Kanatani Y<\/a>, Shinmura Y<\/a>, Yokote H<\/a>, Hashizume S<\/a>. Freeze-dried live attenuated smallpox vaccine prepared in cell culture\u201cLC16-KAKETSUKEN\u201d: Post-marketing surveillance study on safety and efficacy compliant with Good Clinical Practice. Vaccine 2015. 33. 6120\u20136127.<\/li>\n<\/ol>\n\u25b2TOP<\/a>\n2018\u5e743\u6708 \u6539\u8a02<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"\u75c5\u539f\u4f53\u306e\u7279\u5fb4 \u5929\u7136\u75d8\u306e\u75c5\u539f\u4f53\u306f\u3001\u5929\u7136\u75d8\uff08\u75d8\u7621\uff09\u30a6\u30a4\u30eb\u30b9\uff08Variola virus\uff09\u3067\u3042\u308a\u3001\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u79d1\uff08Poxviridae\uff09\u306e\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u5c5e\uff08Genus Orthopox\uff09\u306b\u5206\u985e\u3055\u308c\u308b\u3002\u725b\u75d8\u30a6\u30a4\u30eb\u30b9\u3001\u30ef\u30af\u30b7\u30cb\u2026 \u7d9a\u304d\u3092\u8aad\u3080 »<\/a><\/span><\/p>\n","protected":false},"author":12,"featured_media":0,"parent":100,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/139"}],"collection":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/comments?post=139"}],"version-history":[{"count":17,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/139\/revisions"}],"predecessor-version":[{"id":1394,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/139\/revisions\/1394"}],"up":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/100"}],"wp:attachment":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/media?parent=139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}](\"\/\/h-crisis.niph.go.jp\/bt\/wp-content\/uploads\/sites\/3\/2016\/04\/img_20090217095000.jpg\"){kind=link}