{"id":387,"date":"2016-04-14T14:23:13","date_gmt":"2016-04-14T05:23:13","guid":{"rendered":"http:\/\/h-crisis.niph.go.jp\/bt\/?page_id=387"},"modified":"2020-01-27T17:52:31","modified_gmt":"2020-01-27T08:52:31","slug":"15detail","status":"publish","type":"page","link":"https:\/\/h-crisis.niph.go.jp\/bt\/disease\/15summary\/15detail\/","title":{"rendered":"\u8a73\u7d30\u30fcQ\u71b1"},"content":{"rendered":"<h3>\u75c5\u539f\u4f53\u306e\u7279\u5fb4<\/h3>\n<p>Q\u71b1\u306f<i>Coxiella burnetii<\/i>\u306b\u3088\u308b\u4eba\u7363\u5171\u901a\u611f\u67d3\u75c7\u3067\u3042\u308b\u3002Q\u71b1\u306f\u30011935\u5e74\u306b\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u306e\u30d6\u30ea\u30b9\u30d9\u30f3\u3067\u98df\u8089\u89e3\u4f53\u51e6\u7406\u5834\u306e\u5f93\u696d\u54e1\u306e\u9593\u3067\u6d41\u884c\u3057\u305f\u539f\u56e0\u4e0d\u660e\u306e\u71b1\u6027\u75be\u60a3\u3068\u3057\u3066\u521d\u3081\u3066\u898b\u51fa\u3055\u308c\u3001\u300cquery\uff1d\u4e0d\u660e\u300d\u306e\u982d\u6587\u5b57\u3092\u3068\u308aQ fever\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u305f\u3002\u81ea\u7136\u754c\u3067\u306f\u30de\u30c0\u30cb\u306a\u3069\u306e\u7bc0\u8db3\u52d5\u7269\u3084\u30a8\u30a2\u30ed\u30be\u30eb\u3092\u4ecb\u3057\u3066\u3001\u591a\u304f\u306e\u91ce\u751f\u52d5\u7269\u3001\u9ce5\u985e\u3001\u307e\u305f\u5bb6\u755c\u3084\u611b\u73a9\u52d5\u7269\u304c<i>C. burnetii<\/i>\u3092\u4fdd\u83cc\u3057\u3066\u3044\u308b\u3002\u30d2\u30c8\u3078\u306e\u611f\u67d3\u6e90\u306f\u3001\u5bb6\u755c\u306e\u53cd\u82bb\u52d5\u7269\uff08\u30a6\u30b7\u3001\u30d2\u30c4\u30b8\u3001\u30e4\u30ae\uff09\u3084\u30cd\u30b3\u304c\u591a\u304f\u3001\u7279\u306b\u611f\u67d3\u52d5\u7269\u306e\u80ce\u76e4\u306b\u304a\u3044\u3066\u9ad8\u6fc3\u5ea6\u306b\u5897\u6b96\u3059\u308b\u305f\u3081\u3001\u52d5\u7269\u306e\u51fa\u7523\u3001\u6d41\u7523\u6642\u306b\u80ce\u76e4\u3001\u5c3f\u3001\u7cde\u4fbf\u7b49\u306b\u6c5a\u67d3\u3055\u308c\u3001\u75c5\u539f\u4f53\u3092\u542b\u3080\u30a8\u30a2\u30ed\u30be\u30eb\u3092\u5438\u5165\u3057\u3066\u611f\u67d3\u3059\u308b\u3002\u7d4c\u53e3\u611f\u67d3\u3068\u3057\u3066\u3001\u4e3b\u306b\u30a6\u30b7\u3084\u30d2\u30c4\u30b8\u306e\u672a\u6bba\u83cc\u751f\u4e73\u3084\u4e73\u88fd\u54c1\u3092\u6442\u98df\u3057\u611f\u67d3\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u304d\u305f\u304c\u3001\u5b9f\u969b\u306b\u306f\u307e\u308c\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\uff31\u71b1\u306e\u60a3\u8005\u306f\u6b27\u7c73\u3084\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u3067\u306f\u5e74\u959350\uff5e500\u4f8b\u7a0b\u5ea6\u306e\u5831\u544a\u304c\u3042\u308b\u3002\u308f\u304c\u56fd\u3067\u306f\u611f\u67d3\u75c7\u6cd5\u306e\uff14\u985e\u611f\u67d3\u75c7\u3067\u3042\u308a\u5e74\u306b\u6570\u4f8b\uff5e40\u4f8b\u7a0b\u5ea6\u306e\u5831\u544a\u304c\u3042\u308b\u3002<\/p>\n<p><i>C. burnetii<\/i>\u306f\u3001\u5f93\u6765\u30ea\u30b1\u30c3\u30c1\u30a2\u306b\u5206\u985e\u3055\u308c\u3066\u3044\u305f\u304c\u3001\u6700\u8fd1\u306e\u907a\u4f1d\u5b50\u5b66\u7684\u306a\u89e3\u6790\u306b\u3088\u308b\u5206\u985e\u3067\u306f\u3001\u30ec\u30b8\u30aa\u30cd\u30e9\u76ee\u30b3\u30af\u30b7\u30a8\u30e9\u79d1\u30b3\u30af\u30b7\u30a8\u30e9\u5c5e\u306b\u5909\u66f4\u3055\u308c\u305f\u3002\u7d30\u80de\u5185\u3067\u306e\u307f\u5897\u6b96\u3067\u304d\u308b\u504f\u6027\u7d30\u80de\u5185\u5bc4\u751f\u7d30\u83cc\u3067\u3042\u308a\u3001\u305d\u306e\u5927\u304d\u3055\u306f0.2\uff5e0.4\u00d71.0\u03bcm\u3067\u3001\u83cc\u306e\u5f62\u614b\u306b\u306f\u5927\u578b\u83cc\u4f53\uff08LCV\uff09\u3068\u5c0f\u578b\u83cc\u4f53\uff08SCV\uff09\u3068\u304c\u3042\u308b\u3002\u3068\u3082\u306b\u611f\u67d3\u6027\u304c\u3042\u308a\u3001LCV \u306f\u6d78\u900f\u5727\u306b\u5bfe\u3057\u62b5\u6297\u6027\u304c\u4f4e\u3044\u304c\u3001SCV \u306f\u82bd\u80de\u69d8\u69cb\u9020\u3092\u793a\u3057\u3001\u71b1\u3001\u4e7e\u71e5\u3001\u6d88\u6bd2\u7b49\u306b\u62b5\u6297\u6027\u306e\u305f\u3081\u74b0\u5883\u4e2d\u3067\u9577\u671f\u9593\u5b89\u5b9a\u3067\u3042\u308b\u3002\u305d\u306e\u305f\u3081\u30d0\u30a4\u30aa\u30c6\u30ed\u30ea\u30ba\u30e0\u3068\u3057\u3066\u3001\u611f\u67d3\u6027\u306e\u30a8\u30a2\u30ed\u30be\u30eb\u306e\u6563\u5e03\u3084\u98df\u54c1\u7b49\u3078\u306e\u6df7\u5165\u306e\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p style=\"text-align: right\"><a title=\"Q\u71b1 \u2013 Q fever\uff08\u8a73\u7d30\uff09\" href=\"\/\/h-crisis.niph.go.jp\/bt\/disease\/15summary\/15detail\/\">\u25b2TOP<\/a><\/p>\n<h3>\u4e3b\u306a\u81e8\u5e8a\u50cf<\/h3>\n<p><i>C. burnetii<\/i>\u306b\u611f\u67d3\u3057\u3066\u3082\u3001\u7d04\u534a\u6570\u306f\u4e0d\u9855\u6027\u611f\u67d3\u306e\u307e\u307e\u53ce\u675f\u3059\u308b\u3002\u767a\u75c7\u3057\u305f\u5834\u5408\u3001\u75c5\u614b\u306f\u5927\u304d\u304f\u6025\u6027\u578b(\u6025\u6027Q\u71b1)\u3068\u6162\u6027\u578b(\u6162\u6027Q\u71b1)\u306b\u5206\u3051\u3089\u308c\u308b\u3002\u6025\u6027Q\u71b1\u306e\u6f5c\u4f0f\u671f\u9593\u306f\u4e00\u822c\u7684\u306b\u306f2\uff5e3\u9031\u9593\u3067\u3001\u611f\u67d3\u91cf\u304c\u591a\u3044\u3068\u77ed\u304f\u306a\u308b\u3002\u81e8\u5e8a\u75c7\u72b6\u306f\u3001\u7a81\u7136\u306e\u9ad8\u71b1\u3001\u60aa\u5bd2\u3001\u982d\u75db\u3001\u60aa\u5fc3\u3001\u6fc0\u3057\u3044\u5026\u6020\u611f\u3001\u7b4b\u8089\u75db\u306a\u3069\u306e\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u69d8\u75c7\u72b6\u3092\u793a\u3059\u3002\u80f8\u75db\u3092\u4f34\u3046\u3053\u3068\u304c\u591a\u3044\u3002\u591a\u304f\u306f\u7121\u6cbb\u7642\u3067\u3082\uff17\uff5e10\u65e5\u3067\u56de\u5fa9\u3059\u308b\u304c\u3001\u4e00\u90e8\u91cd\u75c7\u5316\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u3002\u4e3b\u75c7\u72b6\u306b\u3088\u308a\u3001\u300c\u80ba\u708e\u578b\u300d\u300c\u809d\u708e\u578b\u300d\u300c\u4e0d\u660e\u71b1\u578b\u300d\u306e3\u30d1\u30bf\u30fc\u30f3\u304c\u3042\u308b\u304c\u3001\u3042\u307e\u308aQ\u71b1\u3068\u3057\u3066\u7279\u5fb4\u7684\u306a\u3082\u306e\u306f\u306a\u3044\u3002\u76ae\u75b9\u306f\u7a00\u3067\u3042\u308b\u3002\u80ba\u708e\u578b\u3067\u306f\u4f4e\u9178\u7d20\u8840\u75c7\u3092\u5448\u3059\u308b\u4f8b\u3082\u3042\u308a\u3001\u81e8\u5e8a\u50cf\u306f\u6bd4\u8f03\u7684\u91cd\u3044\u3002\u809d\u708e\u578b\u3067\u306f\u809d\u816b\u5927\u3001\u813e\u816b\u3001\u53f3\u4e0a\u8179\u90e8\u75db\u306a\u3069\u304c\u307f\u3089\u308c\u308b\u3002\u4e0d\u660e\u71b1\u578b\u306f\u767a\u71b1\u4ee5\u5916\u306e\u75c7\u72b6\u306f\u6bd4\u8f03\u7684\u8efd\u3044\u3002\u5408\u4f75\u75c7\u3068\u3057\u3066\u9ac4\u819c\u8133\u708e\u3001\u6eb6\u8840\u6027\u8ca7\u8840\u3001\u7e26\u9694\u30ea\u30f3\u30d1\u7bc0\u816b\u8139\u3001\u7d50\u7bc0\u6027\u7d05\u6591\u3001\u7532\u72b6\u817a\u708e\u3001\u81b5\u81d3\u708e\u3001\u8996\u795e\u7d4c\u708e\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u307e\u305f\u3001\u598a\u5a20\u521d\u671f\u306b\u611f\u67d3\u3059\u308b\u3068\u81ea\u7136\u6d41\u7523\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u9451\u5225\u75be\u60a3\u3068\u3057\u3066\u306f\u75c7\u72b6\u304c\u975e\u7279\u7570\u7684\u306a\u305f\u3081\u3001\u767a\u71b1\u75be\u60a3\u5168\u822c\u304c\u9451\u5225\u8a3a\u65ad\u306e\u5bfe\u8c61\u3068\u306a\u308b\u3002\u80ba\u708e\u3067\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u6027\u80ba\u708e\u3001\u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u80ba\u708e\u3001\u80ba\u708e\u30af\u30e9\u30df\u30b8\u30a2\u80ba\u708e\u3001\u30aa\u30a6\u30e0\u75c5\u3001\u30ec\u30b8\u30aa\u30cd\u30e9\u80ba\u708e\u3068\u9451\u5225\u3092\u8981\u3059\u308b\u3002<\/p>\n<p>\u307e\u305f\u3001\u6025\u6027Q\u71b1\u306e2\uff5e10%\u306f\u5fc3\u5185\u819c\u708e\u3092\u4e3b\u5fb4\u3068\u3059\u308b\u6162\u6027\u578b\u306b\u79fb\u884c\u3059\u308b\u3068\u3055\u308c\u3001\u96e3\u6cbb\u6027\u3068\u306a\u308b\u3002\u6025\u6027Q\u71b1\u60a3\u8005\u304c\u56de\u5fa9\u5f8c\u3001\u5026\u6020\u611f\u3001\u4e0d\u7720\u3001\u95a2\u7bc0\u75db\u306a\u3069\u304c\u3001\u9577\u671f\u9593\u6301\u7d9a\u3057\u3001\u6025\u6027Q\u71b1\u5f8c\u75c7\u5019\u7fa4(post Q fever fatigue syndrome:QFS)\u3068\u8a3a\u65ad\u3055\u308c\u308b\u75c7\u4f8b\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u307e\u3060\u5b9f\u614b\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u3044\u3002\u3055\u3089\u306b\u6162\u6027\u75b2\u52b4\u75c7\u5019\u7fa4\u3068\u306e\u95a2\u4fc2\u3092\u6307\u6458\u3059\u308b\u5831\u544a\u3082\u3042\u308b\u304c\u3001\u307e\u3060\u898b\u89e3\u304c\u5b9a\u307e\u3063\u3066\u3044\u306a\u3044\u3002<\/p>\n<p style=\"text-align: right\"><a title=\"Q\u71b1 \u2013 Q fever\uff08\u8a73\u7d30\uff09\" href=\"\/\/h-crisis.niph.go.jp\/bt\/disease\/15summary\/15detail\/\">\u25b2TOP<\/a><\/p>\n<h3>\u81e8\u5e8a\u691c\u67fb\u6240\u898b<\/h3>\n<h4>\u8840\u6db2\u751f\u5316\u5b66\u691c\u67fb<\/h4>\n<p>CRP\u4e0a\u6607\u3001\u8d64\u6c88\u306e\u9ad8\u5ea6\u4ea2\u9032\u3001\u809d\u9175\u7d20\u306eAST(GOT)\u3001ALT(GPT\uff09\u306e\u4e2d\u7b49\u5ea6\u4e0a\u6607\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u3001\u8ca7\u8840\u306a\u3069\u304c\u307f\u3089\u308c\u308b\u3002\u307b\u3068\u3093\u3069\u304c\u6b63\u5e38\u306a\u767d\u8840\u7403\u6570\u3092\u793a\u3059\u3082\u306e\u306e\u3001\u767d\u8840\u7403\u6570\u4f4e\u4e0b\u3001\u5897\u52a0\u306e\u5831\u544a\u3082\u3042\u308b\u3002<\/p>\n<h4>\u753b\u50cf\u691c\u67fb\u305d\u306e\u4ed6<\/h4>\n<p>\u80ba\u708e\u306e\u80f8\u90e8X\u7dda\u50cf\u3001CT\u50cf\u306b\u306f\u3001\u3042\u307e\u308a\u7279\u5fb4\u7684\u306a\u3082\u306e\u306f\u306a\u3044\u304c\u3001\u7d30\u6c17\u7ba1\u652f\u3084\u8840\u7ba1\u5468\u56f2\u306e\u708e\u75c7\u304c\u4e3b\u4f53\u3067\u3042\u308a\u3001\u4e3b\u306b\u9593\u8cea\u6027\u80ba\u708e\u50cf\u3092\u5448\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3002\u809d\u708e\u578b\u3067\u306f\u3001\u8179\u90e8CT\u3067\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u809d\u813e\u816b\u304c\u307f\u3089\u308c\u308b\u3002\u809d\u751f\u691c\u3067\u306f\u3001\u3073\u6f2b\u6027\u306e\u8089\u82bd\u816b\u6027\u5909\u5316\u3092\u4f34\u3046\u75c5\u7406\u6240\u898b\u304c\u7279\u5fb4\u3068\u3055\u308c\u308b\u3002<\/p>\n<p style=\"text-align: right\"><a title=\"Q\u71b1 \u2013 Q fever\uff08\u8a73\u7d30\uff09\" href=\"\/\/h-crisis.niph.go.jp\/bt\/disease\/15summary\/15detail\/\">\u25b2TOP<\/a><\/p>\n<h3>\u78ba\u5b9a\u8a3a\u65ad<\/h3>\n<h4>\u691c\u4f53\u306e\u63a1\u53d6\u3001\u8f38\u9001\u3001\u4fdd\u5b58\u306a\u3069<\/h4>\n<p>\u30d2\u30c8\u304b\u3089\u306e\u6750\u6599\u306f\u8840\u6db2\u3001\u8840\u6e05\u3001\u8840\u6f3f\u3001\u54bd\u982d\u30b9\u30ef\u30d6\u3001\u6c17\u9053\u5206\u6ccc\u7269\u3001\u7d44\u7e54\u3001\u81d3\u5668\u306a\u3069\u3092\u63a1\u53d6\u3059\u308b\u3002\u52d5\u7269\u304b\u3089\u306e\u6750\u6599\u306f\u8840\u6db2\u3001\u8840\u6e05\u3001\u4e73\u3001\u813e\u81d3\u3001\u80ce\u5150\u3001\u80ce\u76e4\u3001\u81a3\u306c\u3050\u3044\u6db2\u306a\u3069\u3092\u63a1\u53d6\u3059\u308b\u3002\u98df\u54c1\u3084\u74b0\u5883\u6750\u6599\u306f\u305d\u306e\u307e\u307e\u5bc6\u5c01\u5bb9\u5668\u306b\u63a1\u53d6\u3059\u308b\u3002\u8840\u6e05\u3001\u8840\u6f3f\u3001\u54bd\u982d\u30b9\u30ef\u30d6\u3001\u98df\u54c1\u3084\u74b0\u5883\u6750\u6599\u306f\u51b7\u8535\u307e\u305f\u306f-80\u2103\u306b\u3066\u4fdd\u5b58\u30fb\u8f38\u9001\u3059\u308b\u3002\u8840\u6db2\u3001\u7d44\u7e54\u3084\u81d3\u5668\u306b\u3064\u3044\u3066\u306f\u51b7\u8535\u72b6\u614b\u306b\u3066\u8f38\u9001\u3059\u308b\u3002\u65e9\u671d\u7a7a\u8179\u6642\u306e\u80c3\u6db2\u691c\u67fb\u306f\u3001\u5580\u75f0\u63a1\u53d6\u306e\u56f0\u96e3\u306a\u5c0f\u5150\u3067\u306f\u3001\u7279\u306b\u6709\u52b9\u3002<\/p>\n<h4>\u5fae\u751f\u7269\u5b66\u7684\u691c\u67fb\u6cd5<\/h4>\n<ol>\n<li>\u75c5\u539f\u4f53\u691c\u51fa\u6cd5\n<ul>\n<li>\u5206\u96e2\u57f9\u990a\u6cd5<br \/>\n\u30de\u30a6\u30b9\u307e\u305f\u306f\u30e2\u30eb\u30e2\u30c3\u30c8\u306e\u8179\u8154\u306b\u81e8\u5e8a\u6750\u6599\u3092\u63a5\u7a2e\u3057\u3001\u8840\u6db2\u3001\u813e\u81d3\u304b\u3089\u5206\u96e2\u3055\u308c\u305f\u83cc\u682a\u3092\u540c\u5b9a\u3059\u308b\u3002\u30b9\u30ad\u30c3\u30c9\u30de\u30a6\u30b9\u3084\u514d\u75ab\u6291\u5236\u5264\u3092\u6295\u4e0e\u3057\u305f\u30de\u30a6\u30b9\u3092\u7528\u3044\u308b\u3068\u52b9\u7387\u304c\u826f\u3044\u3002\u767a\u80b2\u9d8f\u5375\u3092\u7528\u3044\u308b\u5834\u5408\u306f\u3001\u5375\u9ec4\u56a2\u5185\u63a5\u7a2e\u306b\u3088\u308a\u83cc\u3092\u5897\u6b96\u3055\u305b\u3001\u7d30\u80de\u57f9\u990a\u306e\u5834\u5408\u3067\u306f\u3001BGM(buffalo green monkey:\u30a2\u30d5\u30ea\u30ab\u30df\u30c9\u30ea\u30b6\u30eb\u814e\u81d3)\u7d30\u80de\u306a\u3069\u3092\u7528\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u64cd\u4f5c\u306f\u3044\u305a\u308c\u3082P3\u30ec\u30d9\u30eb\u306e\u611f\u67d3\u5b9f\u9a13\u304c\u53ef\u80fd\u306a\u8a2d\u5099\u3092\u8981\u3057\u4e00\u822c\u7684\u3067\u306f\u306a\u3044\u3002<\/li>\n<li>\u6297\u539f\u691c\u51fa\u6cd5<br \/>\n\u81e8\u5e8a\u691c\u4f53\u3092\u76f4\u63a5\u30d2\u30e1\u30cd\u30b9\u67d3\u8272\u3084\u30ae\u30e0\u30b6\u67d3\u8272\u3001\u3042\u308b\u3044\u306f\u514d\u75ab\u86cd\u5149\u6297\u4f53\u6cd5\u306b\u3066\u67d3\u8272\u3059\u308b\u304c\u3001\u4e0d\u78ba\u5b9f\u3067\u3042\u308b\u3002<\/li>\n<li>\u907a\u4f1d\u5b50\u691c\u51fa\u6cd5<br \/>\n<i>C. burnetii<\/i>\u306e\u5916\u819c\u30bf\u30f3\u30d1\u30af\u3092\u30b3\u30fc\u30c9\u3059\u308bcom1\u907a\u4f1d\u5b50\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u305fNested PCR\u6cd5\u304c\u4e00\u822c\u306b\u884c\u308f\u308c\u3066\u3044\u308b\u3002\u4e3b\u306b\u3001\u5168\u8840\u306e\u30d0\u30d5\u30a3\u30fc\u30b3\u30fc\u30c8\u5206\u753b\u304b\u3089\u691c\u51fa\u3092\u884c\u3063\u3066\u304a\u308a\u3001\u6025\u6027\u6975\u671f\u306b\u306f\u8840\u6e05\u4e2d\u304b\u3089\u306e\u691c\u51fa\u3082\u53ef\u80fd\u3067\u3042\u308b\u3002\u307e\u305f\u3001\u7c21\u4fbf\u304b\u3064\u8fc5\u901f\u306a\u65b0\u3057\u3044\u691c\u51fa\u6cd5\u306e\u78ba\u7acb\u3092\u76ee\u7684\u306bTaqMan probe\u3092\u7528\u3044\u305fReal Time PCR\u6cd5\u3084LAMP\u6cd5\u304c\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u3002(\u8a73\u7d30\u306f\u611f\u67d3\u7814\u306e\u75c5\u539f\u4f53\u691c\u67fb\u30de\u30cb\u30e5\u30a2\u30eb\u3092\u53c2\u7167\u3055\u308c\u305f\u3044)<\/li>\n<\/ul>\n<\/li>\n<li>\u8840\u6e05\u6297\u4f53\u6e2c\u5b9a\u6cd5\n<ul>\n<li>\u9593\u63a5\u86cd\u5149\u6297\u4f53\u6cd5\uff08IFA\u6cd5\uff09<br \/>\n\u8840\u6e05\u6297\u4f53\u6e2c\u5b9a\u306e\u6a19\u6e96\u6cd5\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002\u611f\u67d3\u7d30\u80de\u3042\u308b\u3044\u306f\u7cbe\u88fd\u6297\u539f\u3092\u7528\u3044\u308b\u3002\u611f\u67d3\u7d30\u80de\u3092\u7528\u3044\u308b\u5834\u5408\u306f\u7d30\u80de\u5916\u306e\u7c92\u5b50\u306e\u7279\u7570\u7684\u306a\u86cd\u5149\u3092\u8a8d\u3081\u308b\u5834\u5408\u3092\u967d\u6027\u3068\u3059\u308b\u3002\u5224\u5b9a\u306b\u306f\u3042\u308b\u7a0b\u5ea6\u306e\u7d4c\u9a13\u3092\u8981\u3057\u3001\u967d\u6027\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u304a\u3044\u305f\u5224\u5b9a\u304c\u671b\u307e\u3057\u3044\u3002\u6025\u6027\u671f\u306e\u8840\u6e05\u3067\u306fII\u76f8\u83cc\u306b\u5bfe\u3059\u308b\u6297\u4f53\u4fa1\u306e\u4e0a\u6607\u304cI\u76f8\u83cc\u306b\u6bd4\u3079\u512a\u4f4d\u3067\u3001\u6162\u6027\u671f\u3067\u306fI\u76f8\u83cc\u306b\u5bfe\u3059\u308b\u6297\u4f53\u4fa1\u306e\u4e0a\u6607\u304c\u512a\u4f4d\u3067\u3042\u308b\u3002\u539f\u5247\u7684\u306b\u6025\u6027\u671f\u3068\u56de\u5fa9\u671f\u306e\u30da\u30a2\u8840\u6e05\u3092\u7528\u3044\u3001IgG\u6297\u4f53\u4fa1\u306e4\u500d\u4e0a\u6607\u304c\u8a8d\u3081\u3089\u308c\u308b\u3082\u306e\u3092\u967d\u6027\u3068\u3059\u308b\u3002\u30b7\u30f3\u30b0\u30eb\u8840\u6e05\u306e\u5834\u5408\u3001IgM\u6297\u4f53\u4fa116\u301c32\u500d\u4ee5\u4e0a\u3042\u308b\u3044\u306fIgG\u6297\u4f53\u4fa1128\u301c256\u500d\u4ee5\u4e0a\u3092\u967d\u6027\u3068\u3059\u308b\u3002(\u8a73\u7d30\u306f\u611f\u67d3\u7814\u306e\u75c5\u539f\u4f53\u691c\u67fb\u30de\u30cb\u30e5\u30a2\u30eb\u3092\u53c2\u7167\u3055\u308c\u305f\u3044)<\/li>\n<li>\u9175\u7d20\u514d\u75ab\u6297\u4f53\u6cd5\uff08ELISA\u6cd5\uff09<br \/>\n\u8f38\u5165\u30ad\u30c3\u30c8\u3067\u3042\u308bELISA\u30ad\u30c3\u30c8(PanBio\u793e\u88fd)\u306b\u3088\u308b\u6297\u4f53\u6e2c\u5b9a\u3082\u884c\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u308b\u3002\u305f\u3060\u3057\u30ab\u30c3\u30c8\u30aa\u30d5\u5024\u306b\u8fd1\u3044\u4f4e\u5024\u967d\u6027\u3067\u306e\u5224\u5b9a\u306f\u614e\u91cd\u306b\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u3001IFA\u6cd5\u3067\u306e\u78ba\u8a8d\u3084\u3001\u4e21\u8005\u304c\u4e00\u81f4\u3057\u306a\u3044\u5834\u5408\u306fWestern blot\u3067\u306e\u7279\u7570\u53cd\u5fdc\u30bf\u30f3\u30d1\u30af\u306e\u78ba\u8a8d\u304c\u671b\u307e\u3057\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p style=\"text-align: right\"><a title=\"Q\u71b1 \u2013 Q fever\uff08\u8a73\u7d30\uff09\" href=\"\/\/h-crisis.niph.go.jp\/bt\/disease\/15summary\/15detail\/\">\u25b2TOP<\/a><\/p>\n<h3>\u6cbb\u7642<\/h3>\n<h4>\u85ac\u7269\u7642\u6cd5\uff08\u6297\u83cc\u85ac\u7642\u6cd5\uff09<\/h4>\n<p>\u6025\u6027Q\u71b1\u306e\u591a\u304f\u306f2\u9031\u9593\u7a0b\u5ea6\u3067\u81ea\u7136\u6cbb\u7652\u3057\u3001\u6b7b\u4ea1\u4f8b\u306f\u307e\u308c\u3067\u3042\u308b\u304c\u3001\u6297\u83cc\u85ac\u306b\u3088\u308b\u6cbb\u7642\u3092\u767a\u75c7\u304b\u30893\u65e5\u4ee5\u5185\u306b\u884c\u3046\u3068\u6709\u71b1\u671f\u9593\u306e\u77ed\u7e2e\u3084\u6162\u6027\u5316\u306e\u4e88\u9632\u306b\u52b9\u679c\u304c\u3042\u308b\u3002\u6025\u6027Q\u71b1\u306e\u7b2c\u4e00\u9078\u629e\u85ac\u306f\u30c6\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u7cfb\u6297\u83cc\u85ac(\u30df\u30ce\u30b5\u30a4\u30af\u30ea\u30f3\u30fb\u30c9\u30ad\u30b7\u30b5\u30a4\u30af\u30ea\u30f3)\u3067\u3001\u7b2c\u4e8c\u9078\u629e\u85ac\u3068\u3057\u3066\u30de\u30af\u30ed\u30e9\u30a4\u30c9\u7cfb\u304c\u7528\u3044\u3089\u308c\u308b\u304c\u3001\u91cd\u75c7\u4f8b\u3067\u306f\u7121\u52b9\u306e\u5831\u544a\u3082\u3042\u308b\u3002\u03b2-\u30e9\u30af\u30bf\u30e0\u85ac\u306f\u307b\u307c\u7121\u52b9\u3067\u3042\u308b\u3002\u4ed6\u306b\u306f\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\u3001\u30cb\u30e5\u30fc\u30ad\u30ce\u30ed\u30f3\u85ac\u3082\u6709\u52b9\u3068\u3055\u308c\u308b\u304c\u3001\u30cb\u30e5\u30fc\u30ad\u30ce\u30ed\u30f3\u8010\u6027\u682a\u306e\u5831\u544a\u304c\u3042\u308b\u3002\u83cc\u306e\u9670\u6027\u5316\u3092\u671f\u5f85\u3059\u308b\u305f\u3081\u306b\u306f\u89e3\u71b1\u5f8c\u30822 \u9031\u9593\u306f\u6295\u4e0e\u3092\u7d9a\u3051\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u4eee\u306b\u518d\u71c3\u3057\u305f\u3089\u3001\u3059\u3050\u306b\u6295\u85ac\u3092\u518d\u958b\u3059\u308b\u3002<\/p>\n<p>\u4e00\u65b9\u3001\u6162\u6027Q\u71b1\u306f\u57fa\u672c\u7684\u306b\u6297\u83cc\u85ac\u62b5\u6297\u6027\u3067\u3001\u30c6\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u3068\u30cb\u30e5\u30fc\u30ad\u30ce\u30ed\u30f3\u3001\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\u3001\u30af\u30ed\u30ed\u30ad\u30f3\u306a\u3069\u306e2\u5264\u4f75\u7528\u30673\u5e74\u4ee5\u4e0a\u306e\u7d99\u7d9a\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<h4>\u305d\u306e\u4ed6\u6cbb\u7642\u4e0a\u306e\u7559\u610f\u70b9<\/h4>\n<p>\u6162\u6027Q\u71b1\u306e\u5834\u5408\u306f\u4e88\u5f8c\u304c\u60aa\u304f\u3001\u6570\u5e74\u306b\u308f\u305f\u308b\u6295\u85ac\u304c\u884c\u308f\u308c\u3066\u3082\u5341\u5206\u306b\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u3001\u5f01\u7f6e\u63db\u306a\u3069\u5916\u79d1\u7684\u5bfe\u5fdc\u304c\u5fc5\u8981\u3068\u306a\u308b\u5834\u5408\u3082\u3042\u308b\u3002\u6025\u6027Q\u71b1\u306e\u767a\u75c7\u306e\u969b\u306b\u9069\u5207\u306a\u6cbb\u7642\u3092\u884c\u3044\u3001\u6162\u6027Q\u71b1\u306b\u79fb\u884c\u3055\u305b\u306a\u3044\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/p>\n<p style=\"text-align: right\"><a title=\"Q\u71b1 \u2013 Q fever\uff08\u8a73\u7d30\uff09\" href=\"\/\/h-crisis.niph.go.jp\/bt\/disease\/15summary\/15detail\/\">\u25b2TOP<\/a><\/p>\n<h3>\u4e88\u9632\uff08\u30ef\u30af\u30c1\u30f3\uff09<\/h3>\n<p>\u4e00\u822c\u7684\u306a\u4e88\u9632\u3068\u3057\u3066\u306f\u3001\u5bb6\u755c\u3001\u611b\u73a9\u52d5\u7269\u306e\u51fa\u7523\u6642\u3001\u7279\u306b\u6b7b\u30fb\u6d41\u7523\u306a\u3069\u3092\u304a\u3053\u3057\u305f\u52d5\u7269\u3084\u6392\u6cc4\u7269\u306e\u53d6\u308a\u6271\u3044\u306b\u6ce8\u610f\u3059\u308b\u3002\u6d41\u7523\u80ce\u76e4\u306a\u3069\u306f\u713c\u5374\u3057\u3001\u6c5a\u67d3\u3055\u308c\u305f\u74b0\u5883\u306f\u6b21\u4e9c\u5869\u7d20\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u3084\u30a2\u30eb\u30b3\u30fc\u30eb\u3067\u6d88\u6bd2\u3059\u308b\u3002\u30da\u30c3\u30c8\u3068\u306e\u904e\u5ea6\u306e\u63a5\u89e6\u3092\u3055\u3051\u3001\u89e6\u308c\u305f\u3042\u3068\u306b\u306f\u5fc5\u305a\u624b\u3092\u6d17\u3046\u3002\u307e\u305f\u672a\u6bba\u83cc\u306e\u751f\u4e73\u306e\u98f2\u7528\u306f\u907f\u3051\u308b\u3002<\/p>\n<p>\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b\u4e88\u9632\u306f\u3001\u30d2\u30c8\u306b\u5bfe\u3057\u3066\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u3067\u306f<i>C. burnetii<\/i> I\u76f8\u83cc\u3092\u7cbe\u88fd\u3057\u30db\u30eb\u30de\u30ea\u30f3\u4e0d\u6d3b\u5316\u3057\u305fQ\u71b1\u30ef\u30af\u30c1\u30f3(Q-Vax:Commonwealth Serum Lab)\u304c1989\u5e74\u306b\u958b\u767a\u3055\u308c\u30012000\u5e74\u304b\u3089\u5c60\u755c\u5834\u306e\u5f93\u696d\u54e1\u3084\u98df\u8089\u696d\u8005\u306a\u3069\u30cf\u30a4\u30ea\u30b9\u30af\u7fa4\u306b\u5bfe\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3002\u81e8\u5e8a\u52b9\u679c\u306f\u512a\u308c\u3066\u3044\u308b\u304c\u3001\u4e00\u822c\u306b\u5e83\u304f\u4f7f\u7528\u3059\u308b\u306b\u306f\u526f\u53cd\u5fdc\u306e\u70b9\u3067\u554f\u984c\u304c\u3042\u308a\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u4ee5\u5916\u306e\u56fd\u3067\u306f\u653f\u7b56\u7684\u306a\u5b9f\u65bd\u306f\u306a\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u308f\u304c\u56fd\u3067\u3082\u8a8d\u53ef\u3055\u308c\u3066\u304a\u3089\u305a\u4f7f\u7528\u3067\u304d\u306a\u3044\u3002\u8907\u6570\u56de\u306e\u63a5\u7a2e\u3067\u306f\u63a5\u7a2e\u90e8\u4f4d\u306b\u6fc0\u3057\u3044\u76ae\u75b9\u304c\u51fa\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/p>\n<p style=\"text-align: right\"><a title=\"Q\u71b1 \u2013 Q fever\uff08\u8a73\u7d30\uff09\" href=\"\/\/h-crisis.niph.go.jp\/bt\/disease\/15summary\/15detail\/\">\u25b2TOP<\/a><\/p>\n<h3>\u30d0\u30a4\u30aa\u30cf\u30b6\u30fc\u30c9\u5bfe\u7b56<\/h3>\n<h4>\u60a3\u8005\u306e\u9694\u96e2<\/h4>\n<p>\u30d2\u30c8\u304b\u3089\u30d2\u30c8\u3078\u306e\u611f\u67d3\u306f\u307e\u308c\u3067\u3042\u308a\u3001\u7279\u306b\u9694\u96e2\u3059\u308b\u5fc5\u8981\u306a\u3044\u3002\u305f\u3060\u3057\u598a\u5a66\u60a3\u8005\u306e\u6d41\u7523\u6642\u306e\u80ce\u5150\u3078\u306e\u7d4c\u80ce\u76e4\u611f\u67d3\u3084\u3001\u8f38\u8840\u306b\u3088\u308b\u611f\u67d3\u4e8b\u4f8b\u304c\u3042\u308b\u3002\u307e\u305f\u9662\u5185\u611f\u67d3\u304c\u7591\u308f\u308c\u308b\u4e8b\u4f8b\u306e\u5831\u544a\u304c\u3042\u308a\u3001\u6cbb\u7642\u524d\u306e\u80ba\u708e\u4f8b\u3067\u54b3\u306e\u3042\u308b\u60a3\u8005\u3067\u306f\u3001\u60a3\u8005\u3001\u6cbb\u7642\u8005\u3068\u3082\u30de\u30b9\u30af\u3001\u624b\u6d17\u3044\u3092\u3059\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3002<\/p>\n<h4>\u691c\u4f53\u3001\u83cc\u3001\u6c5a\u67d3\u5668\u6750\u7b49\u306e\u53d6\u308a\u6271\u3044<\/h4>\n<p>\u6cbb\u7642\u524d\u306e\u60a3\u8005\u6c17\u9053\u691c\u4f53\u306e\u53d6\u308a\u6271\u3044\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u611f\u67d3\u6027\u306e\u3042\u308b\u691c\u4f53\u3084\u5206\u96e2\u83cc\u306e\u64cd\u4f5c\u306fP3\u30ec\u30d9\u30eb\u306e\u53d6\u308a\u6271\u3044\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u5b9f\u9a13\u5ba4\u5185\u611f\u67d3\u306e\u5831\u544a\u3082\u3042\u308a\u3001\u6c5a\u67d3\u5668\u6750\u306f\u30af\u30ec\u30be\u30fc\u30eb\u77f3\u3051\u3093\u6db2\u30015%\u904e\u9178\u5316\u6c34\u7d20\u6c34\u3067\u6d88\u6bd2\u3059\u308b\u304b\u3001\u30aa\u30fc\u30c8\u30af\u30ec\u30fc\u30d6\u51e6\u7406\u3092\u884c\u3046\u3002<\/p>\n<p style=\"text-align: right\"><a title=\"Q\u71b1 \u2013 Q fever\uff08\u8a73\u7d30\uff09\" href=\"\/\/h-crisis.niph.go.jp\/bt\/disease\/15summary\/15detail\/\">\u25b2TOP<\/a><\/p>\n<h3>\u53c2\u8003\u6587\u732e<\/h3>\n<ol>\n<li>Derrick EH:Q fever,new fever entry:clinical features,diagnosis and laboratory investigations.Med J Aust 2:281-298,1937.<\/li>\n<li>Burnet FM,Freeman M:Experimental studies of the virus of Q-fever. Med J Aust 2:299-305,1937.<\/li>\n<li>Cox HR:Studies of a filter-passing infections agent isolated from ticks.V.Further attempts to curtivate in cell-free media.Public Health Rep 54:1822-1827,1939.<\/li>\n<li>Oda H, Yoshiie K:Isolation of a <i>Coxiella burnetii<\/i> strain that has low viculence for mice from a patient with acute Q fever. Microbiol Immunol 33:969\u2010973,1989.<\/li>\n<li>Labrenz, M., Hirsch, P.: The genus Coxiella. Garrity, G., Boone, D.R., Castenholz, R.W., Bergey\u2019s manual of systematic bacteriology.2. New York,N.Y., Springer-Verlag. 2003.<\/li>\n<li>Marrie TJ : Q fever volume 1 The disease\uff0e CRC press\uff0c Boca Raton\uff0c 1990\uff0e<\/li>\n<li>Hatchette, T., Hudson, R., Schlech, W., et al.: Caprine-associated Q fever in Newfoundland. Can Commun. Dis.Rap. 26:17-19,2000.<\/li>\n<li>Fishbein, D.B., Raoult, D.: A cluster of <i>Coxiella burnetii<\/i> infections associated with exposure to vaccinated goats and their unpasteurized dairy products.Am.J.Trop.Med.Hyg.47:35-40,1992.<\/li>\n<li>Krumbiegal, E. R., Wisniewski, H.J. :Q fever in the Milwaukee area. Consumption of infected raw milk by human volunteers.Arch. Environ. Health 21:63-65,1970.<\/li>\n<li>Lennette, E.H., Clark, W.H., Abinanti, MM., Covert,J.M. Q fever studies: The effect of pasteurization on <i>Coxiella burnetii<\/i> naturally infected milk. Am. J.Hyg. 55:246-253, 1951.<\/li>\n<li>Williams JC and Thompson HA : Q fever: The biology of <i>Coxiella burnetii<\/i>\uff0e CRC press\uff0c Boca Raton\uff0c 1991\uff0e<\/li>\n<li>Marrie TJ : Epidemiology of Q fever. Q fever, The disease vol.1 (Marrie TJ ,ed),CRC Press Inc, Boca Raton, Fla, p49\u201070,1990.<\/li>\n<li>\u300c\u4e73\u53ca\u3073\u4e73\u88fd\u54c1\u306e\u6210\u5206\u898f\u683c\u7b49\u306b\u95a2\u3059\u308b\u7701\u4ee4\u53ca\u3073\u98df\u54c1,\u6dfb\u52a0\u7269\u7b49\u306e\u898f\u683c\u57fa\u6e96\u306e\u4e00\u90e8\u6539\u6b63\u306b\u3064\u3044\u3066\u300d\u5e73\u621014\u5e7412\u670820\u65e5\u98df\u767a\u7b2c122004\u53f7<\/li>\n<li>\u5cb8\u672c\u5bff\u7537,\u5b89\u85e4\u79c0\u4e8c,\u8352\u5ddd\u9999\u5357\u5b50\u307b\u304b:\u539a\u751f\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1, \u98df\u54c1\u306e\u5b89\u5168\u30fb\u5b89\u5fc3\u78ba\u4fdd\u63a8\u9032\u7814\u7a76\u4e8b\u696d,\u5e73\u621017\u5e74\u5ea6\u7814\u7a76\u5831\u544a\u66f8\u4e26\u3073\u306b\u5e73\u621015\uff5e17\u5e74\u7dcf\u5408\u7814\u7a76\u5831\u544a\u66f8.\u5206\u62c5\u7814\u7a76\u300c\u9d8f\u5375\u304b\u3089\u306eQ\u71b1\u611f\u67d3\u30ea\u30b9\u30af\u306e\u691c\u8a0e\u300d:pp339-349,2006.<\/li>\n<li>Raoult D,Stein A:Q fever during pregnancy-a risk for women,fetuses,and obstetricians.N Engl J Med 330:371, 1994.<\/li>\n<li>Maurine M,Raoult D:Q fever, Clin Microbil; Rev 12:518\u2010553,1999.<\/li>\n<li>Osorio S, et al : Nosocomial transmission of Q fever. J Hosp Infect 54 : 162\u2010168,2003.<\/li>\n<li>Yoshiie K et al: Serological evidence that the Q fever agent (<i>Coxiella burnetii<\/i>) has spread widely among dairy cattle of Japan. Microbiol Immnol 35: 577-581,1991.<\/li>\n<li>Htwe KK, Amano K, Sugiyama Y, et al : Seroepidemiology of <i>Coxiella burnetii<\/i> in domestic and compamnion animals in Japan. Vet Rec 131:490,1992.<\/li>\n<li>Ejericito L.A., et al : Serological Evidence of <i>Coxiella burnetii<\/i> infection in wild animals in Japan. J Wildlife Dis 29 : 481-484,1993.<\/li>\n<li>\u7c73\u56fd\u75be\u75c5\u7ba1\u7406\u4e88\u9632\u30bb\u30f3\u30bf\u30fc <a href=\"http:\/\/www.cdc.gov\/ncidod\/diseases\/programmes\/en\/vph\/cards\/pfever.html\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.cdc.gov\/ncidod\/diseases\/programmes\/en\/vph\/cards\/pfever.html<\/a><\/li>\n<li>\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u4fdd\u5065\u7701 <a href=\"http:\/\/immunise.health.gov.au\/qfever\/index.htm\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/immunise.health.gov.au\/qfever\/index.htm<\/a><\/li>\n<li>Dupiuis, G., Petile, J., Peter, O., Vouilloz, M.:An important ourbreak of human Q fever in a Swiss Alpine valley. Int. J. Epidemiol. 16:262-287,1987.<\/li>\n<li>Kosatsky, T.: Household outbreak of Q-fever pneumonia related to a parturient cat. Lancet.2 :1447-1449, 1984.<\/li>\n<li>Laugley, J.M., Marrie, T.J., Covert, A., et al. : Poker players\u2019peumonia. An urban outbreak of Q fever following exposure to a parturient cat. N. Engl. J.Med. 319:354-556,1988.<\/li>\n<li>\u6cb3\u672c\u77e5\u79c0\uff0c\u5c0f\u5ddd\u57fa\u5f66\uff0c\u5cb8\u672c\u5bff\u7537\u307b\u304b\uff1a\u6d77\u5916\u306e\u5c60\u84c4\u5834\u304a\u3088\u3073\u8fb2\u5834\u3092\u8996\u5bdf\u5f8c\u540c\u6642\u767a\u75c7\u3057\u305fQ\u71b1\u60a3\u80053\u75c7\u4f8b\uff0e\u65e5\u672c\u611f\u67d3\u75c7\u5b66\u96d1\u8a8c76 : 1030-1034\uff0c2003\uff0e<\/li>\n<li>\u5c0f\u5ddd\u57fa\u5f66\uff0c \u6cb3\u672c\u77e5\u79c0\uff0c \u5ddd\u672c \u6b69 \u307b\u304b : \u6025\u6027Q\u71b1\u306e\u8f38\u51653\u75c7\u4f8b\u306b\u304a\u3051\u308b\u8840\u6e05\u6297\u4f53\u4fa1\u306e\u63a8\u79fb\u3068<i>Coxiella burnetii<\/i>\u907a\u4f1d\u5b50\u691c\u51fa\u306e\u9577\u671f\u691c\u8a0e\uff0e\u65e5\u672c\u611f\u67d3\u75c7\u5b66\u96d1\u8a8c77 :127-132\uff0c2003\uff0e<\/li>\n<li>Takahashi H, Tokue Y, Kikuchi T, et al : Prevalence of community\u2010acquired respiratory tract infectons associated with Q fever in Japan. Diagnost Microbiol Infect Dis 48 : 247\u2010252, 2004.<\/li>\n<li>\u6e21\u8fba \u5f70,\u5e73\u4e95\u514b\u54c9,\u767d\u77f3\u5ee3\u884c\u307b\u304b:\uff31\u71b1\u306b\u3088\u308b\u547c\u5438\u5668\u611f\u67d3\u75c7\u306e\u56fd\u5185\u3067\u306e\u767a\u75c7\u72b6\u6cc1\u304a\u3088\u3073\u75c5\u50cf\u306b\u95a2\u3059\u308b\u7814\u7a76.\u539a\u751f\u79d1\u5b66\u7814\u7a76\u30fb\u7814\u7a76\u88dc\u52a9\u91d1,\u65b0\u8208\u30fb\u518d\u8208\u611f\u67d3\u75c7\u7814\u7a76\u4e8b\u696d,\u5e73\u621012\u5e74\u5ea6\u7814\u7a76\u5831\u544a\u66f8\u4e26\u3073\u306b\u5e73\u621010\uff5e12\u5e74\u7dcf\u5408\u7814\u7a76\u5831\u544a\u66f8:pp1-144,2002.<\/li>\n<li>Marmion BP,et al.:Protoracted fatigue and debility after acute Q fever.Lancet 347:977-978,1996.<\/li>\n<li>\u53e4\u5c4b\u7531\u7f8e\u5b50\uff0c\u5c71\u672c\u5fb3\u6804\uff0c\u4f0a\u85e4\u5fe0\u5f66\u307b\u304b:\u30ea\u30b1\u30c3\u30c1\u30a2\u611f\u67d3\u75c7\u8a3a\u65ad\u30de\u30cb\u30e5\u30a2\u30eb\u30fb\u75c5\u539f\u4f53\u691c\u67fb\u30de\u30cb\u30e5\u30a2\u30eb:\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240,\u5730\u65b9\u885b\u751f\u7814\u7a76\u6240\u5168\u56fd\u5354\u8b70\u4f1a\u7de8,2001.<\/li>\n<li>Zhang GQ, Nguyen SV, To H, et al. : Clinical evaluation of a new PCR assay for d<i>etec<\/i>tion of <i>Coxiella burnetii<\/i> in human serum samples. J Clin Microbiol 36 : 77-80, 1998.<\/li>\n<li>Ogawa, M., Setiyono, A., Cai, Y., Sato, K., Shiga, S., Kishimoto, T.: Evaluation of the PCR and Nested PCR Assays Currently Used for D<i>etec<\/i>tion of <i>Coxiella burnetii<\/i> in Japan. Southeat Asian J Trop Med and Public Health. 35: 151-154. 2004.<\/li>\n<li>Dupont HT et al:Clin Diag Lab Immunol 1 :189-196,1994.<\/li>\n<li>Setiyono,A., Ogawa, M., Cai, Y., Shiga, S.,Kishimoto, T., Kurane,I.: New criteria for immunofluorescence assay for Q fever diagnosis in Japan.J.Clin. Microbiol. 43:5555-5559,2005.<\/li>\n<li>Rolain JM, MaurinM, Raoult D: Bacteriostatic and bactericidal activities of moxifloxacin against <i>Coxiella burnetii<\/i>. Antimicrob Agents Chemother 45 : 301\uff0d302, 2001.<\/li>\n<li>CDC Morbidity and Mortality Weekly Report 52 (41) : 924\uff0d927, 2002.<\/li>\n<\/ol>\n<p style=\"text-align: right\"><a title=\"Q\u71b1 \u2013 Q fever\uff08\u8a73\u7d30\uff09\" href=\"\/\/h-crisis.niph.go.jp\/bt\/disease\/15summary\/15detail\/\">\u25b2TOP<\/a><\/p>\n<div class=\"timestamp\" style=\"text-align: right\">2009\u5e7411\u670810\u65e5 16\u664225\u5206 \u6539\u8a02<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u75c5\u539f\u4f53\u306e\u7279\u5fb4 Q\u71b1\u306fCoxiella burnetii\u306b\u3088\u308b\u4eba\u7363\u5171\u901a\u611f\u67d3\u75c7\u3067\u3042\u308b\u3002Q\u71b1\u306f\u30011935\u5e74\u306b\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u306e\u30d6\u30ea\u30b9\u30d9\u30f3\u3067\u98df\u8089\u89e3\u4f53\u51e6\u7406\u5834\u306e\u5f93\u696d\u54e1\u306e\u9593\u3067\u6d41\u884c\u3057\u305f\u539f\u56e0\u4e0d\u660e\u306e\u71b1\u6027\u75be\u60a3\u3068\u3057\u3066\u521d\u3081\u3066\u898b\u51fa\u3055\u308c\u3001\u300cquery\uff1d\u2026 <span class=\"read-more\"><a href=\"https:\/\/h-crisis.niph.go.jp\/bt\/disease\/15summary\/15detail\/\">\u7d9a\u304d\u3092\u8aad\u3080 &raquo;<\/a><\/span><\/p>\n","protected":false},"author":7,"featured_media":0,"parent":134,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/387"}],"collection":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/comments?post=387"}],"version-history":[{"count":9,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/387\/revisions"}],"predecessor-version":[{"id":1090,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/387\/revisions\/1090"}],"up":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/134"}],"wp:attachment":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/media?parent=387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}