{"id":579,"date":"2016-04-16T16:31:33","date_gmt":"2016-04-16T07:31:33","guid":{"rendered":"http:\/\/h-crisis.niph.go.jp\/bt\/?page_id=579"},"modified":"2023-10-24T15:31:39","modified_gmt":"2023-10-24T06:31:39","slug":"30detail","status":"publish","type":"page","link":"https:\/\/h-crisis.niph.go.jp\/bt\/other\/30detail\/","title":{"rendered":"\u30a8\u30e0\u30dd\u30c3\u30af\u30b9(2023.2\u30b5\u30eb\u75d8\u3088\u308a\u540d\u79f0\u5909\u66f4)"},"content":{"rendered":"

\u75c5\u539f\u4f53\u306e\u7279\u5fb4<\/h3>\n

\u30a8\u30e0\u30dd\u30c3\u30af\u30b9(\u30b5\u30eb\u75d8)\u306e\u75c5\u539f\u4f53\u306f\u3001\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u3067\u3001\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u79d1\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u5c5e\u306b\u5206\u985e\u3055\u308c\u308b\u7d04200kbp\u306e\u4e8c\u672c\u9396DNA\u3092\u30b2\u30ce\u30e0\u3068\u3059\u308b\u3002\u30a6\u30a4\u30eb\u30b9\u306e\u5f62\u614b\u306f\u30ec\u30f3\u30ac\u72b6\u3067\u3001\u305d\u306e\u9577\u5f84\u306f300nm\u3092\u8d8a\u3048\u308b\u5de8\u5927\u306a\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308b\uff08\u56f31<\/a>\uff09\u3002\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u306b\u306f\u3001\u5f37\u6bd2\u306a\u30b3\u30f3\u30b4\u76c6\u5730\u578b\u3068\u3084\u3084\u5f31\u6bd2\u306a\u897f\u30a2\u30d5\u30ea\u30ab\u578b\u304c\u3042\u308a\u907a\u4f1d\u7684\u306b\u3082\u8b58\u5225\u3067\u304d\u308b\u3002\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u30a2\u30d5\u30ea\u30ab\u306e\u30b8\u30ea\u30b9\u7b49\u306e\u9f67\u6b6f\u985e\u304c\u81ea\u7136\u5bbf\u4e3b\u3068\u3057\u3001\u30d2\u30c8\u3001\u30b5\u30eb\u3001\u30d7\u30ec\u30fc\u30ea\u30fc\u30c9\u30c3\u30af\u3001\u30a6\u30b5\u30ae\u7b49\u304c\u611f\u67d3\u3059\u308b\u3068\u3001\u5929\u7136\u75d8\u69d8\u306e\u75c7\u72b6\u3092\u5448\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u3001\u725b\u75d8\u30a6\u30a4\u30eb\u30b9\u3001\u30ef\u30af\u30c1\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u7b49\u3082\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u5c5e\u306b\u542b\u307e\u308c\u308b\u3002\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u9593\u3067\u306f\u3001\u6297\u539f\u6027\u306e\u4ea4\u53c9\u304c\u975e\u5e38\u306b\u5f37\u3044\u305f\u3081\u3001\u8840\u6e05\u8a3a\u65ad\u306b\u3088\u308b\u611f\u67d3\u30a6\u30a4\u30eb\u30b9\u7a2e\u306e\u540c\u5b9a\u306f\u3067\u304d\u306a\u3044\u3002\u3053\u306e\u305f\u3081\u3001\u907a\u4f1d\u5b50\u8a3a\u65ad\u304c\u6709\u529b\u306a\u8a3a\u65ad\u6cd5\u3068\u306a\u308b\u3002
\n\u30d2\u30c8\u306e\u30b5\u30eb\u75d8\u306f\u30011970\u5e74\u306b\u30b6\u30a4\u30fc\u30eb\u3067\u5929\u7136\u75d8\u69d8\u75be\u60a3\u3068\u3057\u3066\u521d\u3081\u3066\u5831\u544a\u3055\u308c\u3001\u305d\u306e\u5f8c\u3001\u4e2d\u592e\u30fb\u897f\u30a2\u30d5\u30ea\u30ab\u306e\u4e3b\u306b\u71b1\u5e2f\u96e8\u6797\u3067\u6563\u767a\u7684\u306b\u6d41\u884c\u3057\u3066\u3044\u308b\u3002WHO\u306b\u3088\u308b\u3068\u30011981\u301c1986\u5e74\u306e\u30a8\u30e0\u30dd\u30c3\u30af\u30b9(\u30b5\u30eb\u75d8)\u60a3\u8005\u767a\u751f\u6570\u306f338\u540d\u3067\u3042\u308b\u30021996\u301c1997 \u5e74\u306b\u304b\u3051\u3066\u30b3\u30f3\u30b4\u6c11\u4e3b\u5171\u548c\u56fd\u3067\u306e\u6d41\u884c\u3067\u306f\u60a3\u8005\u767a\u751f\u6570\u306f511\u540d\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u306e\u5f8c\u3082\u30b3\u30f3\u30b4\u6c11\u4e3b\u5171\u548c\u56fd\u3067\u306f\u6d41\u884c\u3057\u3066\u3044\u308b\u3002\u30a2\u30d5\u30ea\u30ab\u5927\u9678\u4ee5\u5916\u306b\u306f\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u4fdd\u6709\u52d5\u7269\u306f\u3044\u306a\u3044\u304c\u30012003\u5e74\u306b\u7c73\u56fd\u3067\u30ac\u30fc\u30ca\u304b\u3089\u8f38\u5165\u3055\u308c\u305f\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u611b\u73a9\u7528\u9f67\u6b6f\u985e\u9f67\u6b6f\u985e\uff08\u30b5\u30d0\u30f3\u30ca\u30aa\u30cb\u30cd\u30ba\u30df\u3001\u30a2\u30d5\u30ea\u30ab\u30e4\u30de\u30cd\uff09\u304b\u3089\u30d7\u30ec\u30fc\u30ea\u30fc\u30c9\u30c3\u30b0\u306b\u611f\u67d3\u304c\u5e83\u304c\u308a\u3001\u3053\u308c\u3092\u611f\u67d3\u6e90\u3068\u3059\u308b\u6d41\u884c\u306b\u3088\u308a71\u540d\u306e\u30b5\u30eb\u75d8\u60a3\u8005\u304c\u767a\u751f\u3057\u305f\u3002\u3053\u306e\u6d41\u884c\u3067\u306f\u3001\u75c5\u539f\u30a6\u30a4\u30eb\u30b9\u304c\u5f31\u6bd2\u306a\u897f\u30a2\u30d5\u30ea\u30ab\u578b\u3067\u3042\u3063\u305f\u305f\u3081\u3001\u6b7b\u4ea1\u4f8b\u306f\u767a\u751f\u3057\u3066\u3044\u306a\u3044\u3002\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u306e\u30d2\u30c8\u3078\u306e\u4e3b\u306a\u611f\u67d3\u7d4c\u8def\u306f\u3001\u611f\u67d3\u52d5\u7269\u306b\u3088\u308b\u54ac\u50b7\u3001\u611f\u67d3\u52d5\u7269\u306e\u8840\u6db2\u30fb\u4f53\u6db2\u30fb\u76ae\u819a\u75c5\u5909\u7b49\u3068\u306e\u63a5\u89e6\u306b\u3088\u308b\u3002\u30b5\u30eb\u75d8\u306e\u81f4\u6b7b\u7387\u306f1\u301c10%\u7a0b\u5ea6\u3067\u3001\u60a3\u8005\u304b\u3089\u306e\u4e8c\u6b21\u611f\u67d3\u7387\u306f\u6570\uff05\u7a0b\u5ea6\u3067\u3042\u308b\u3002
\n\u65e5\u672c\u3067\u306e\u30a2\u30d5\u30ea\u30ab\u304b\u3089\u306e\u8f38\u5165\u7981\u6b62\u9f67\u6b6f\u985e\u306f\u3001\u30e9\u30c3\u30b5\u30a6\u30a4\u30eb\u30b9\u306e\u81ea\u7136\u5bbf\u4e3b\u3067\u3042\u308b\u30de\u30b9\u30c8\u30df\u30b9\u306e\u307f\u3067\u3042\u308b\u305f\u3081\u3001\u8f38\u5165\u611f\u67d3\u75c7\u3068\u3057\u3066\u3060\u3051\u3067\u306f\u306a\u304f\u8f38\u5165\u52d5\u7269\u3092\u4ecb\u3057\u305f\u60a3\u8005\u304c\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u306f\u5426\u5b9a\u3067\u304d\u306a\u3044\u3002<\/p>\n

2022\u5e745\u6708\u306b\u82f1\u56fd\u53ca\u3073\u7c73\u56fd\u3067\u56fd\u5185\u611f\u67d3\u4f8b\u304c\u78ba\u8a8d\u3055\u308c\u3001\u305d\u306e\u5f8c\u6b27\u7c73\u3067\u306e\u6d41\u884c\u304c\u898b\u3089\u308c\u305f\u3002\u65e5\u672c\u3067\u306f2023\u5e74\u306b\u5165\u308a\u3001\u56fd\u5185\u611f\u67d3\u4e8b\u4f8b\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u5831\u544a\u4f8b\u306fMSM(men who have sex men)\u304c\u4e3b\u306a\u30dd\u30d4\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u3042\u308a\u3001\u534a\u6570\u304cPWH(people with HIV)\u3067\u3042\u308a\u3001\u6027\u884c\u70ba\u3092\u4ecb\u3057\u3066\u4f1d\u64ad\u3057\u3066\u3044\u308b\u3002\u897f\u30a2\u30d5\u30ea\u30ab\u578b\u304c\u8d77\u6e90\u3067\u3042\u308a\u3001\u8efd\u75c7\u4f8b\u304c\u5927\u90e8\u5206\u3067\u3042\u308b\u304c\u3001\u514d\u75ab\u4e0d\u5168\u8005\u3067\u306f\u9ad8\u3044\u81f4\u6b7b\u7387\u3067\u3042\u308a\u3001\u6700\u7d42\u7684\u306a\u5831\u544a\u304c\u5f85\u305f\u308c\u308b\u3002\u76f4\u63a5\u306e\u63a5\u89e6\u611f\u67d3\u304c\u4e3b\u306a\u611f\u67d3\u7d4c\u8def\u3067\u3001\u6027\u884c\u70ba\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u304b\u3089\u3001\u76ae\u75b9\u306e\u51fa\u73fe\u30d1\u30bf\u30fc\u30f3\u306a\u3069\u306f\u3001\u30a2\u30d5\u30ea\u30ab\u8af8\u56fd\u3067\u306e\u3053\u308c\u307e\u3067\u306e\u81e8\u5e8a\u50cf\u3068\u7570\u306a\u308b\u304c\u3001\u6025\u6027\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u3067\u3042\u308a\u3001\u57fa\u672c\u7684\u306a\u75c5\u614b\u306f\u7570\u306a\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3002\u30d0\u30a4\u30aa\u30c6\u30ed\u3084\u65b0\u898f\u306e\u6d41\u884c\u8d77\u3053\u3063\u305f\u5834\u5408\u3001\u611f\u67d3\u7d4c\u8def\u306b\u4f9d\u5b58\u3057\u3046\u308b\u3001\u76ae\u75b9\u306e\u51fa\u73fe\u5834\u6240\u3084\u30d1\u30bf\u30fc\u30f3\u306b\u3053\u3060\u308f\u308b\u3053\u3068\u306a\u304f\u8003\u3048\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u4e3b\u306a\u81e8\u5e8a\u50cf<\/h3>\n

\u6f5c\u4f0f\u671f\u9593\u306f7\u301c21\u65e5\uff08\u5e73\u574712\u65e5\uff09\u3067\u3001\u767a\u75b9\u3001\u767a\u71b1\u3001\u767a\u6c57\u3001\u982d\u75db\u3001\u60aa\u5bd2\u3001\u54bd\u982d\u75db\u3001\u30ea\u30f3\u30d1\u7bc0\u816b\u8139\u304c\u73fe\u308c\u308b\u3002\u767a\u75b9\u306f\u3001\u6c34\u75b1\u3001\u81bf\u75b1\u3001\u75c2\u76ae\u3078\u3068\u9032\u884c\u3059\u308b\u3002\u91cd\u75c7\u4f8b\u3067\u306f\u5929\u7136\u75d8\u3068\u81e8\u5e8a\u7684\u306b\u533a\u5225\u3067\u304d\u306a\u3044 (\u56f32<\/a>)\u30022022\u5e74\u5ea6\u304b\u3089\u306eMSM(men who have sex with men)\u9593\u3067\u30d2\u30c8\u30fc\u30d2\u30c8\u9593\u3067\u6d41\u884c\u3057\u305f\u30b1\u30fc\u30b9\u304b\u3089\u306f\u63a5\u89e6\u90e8\u4f4d\u306b\u767a\u75b9\u304c\u51fa\u73fe\u3057\u3066\u3044\u308b\u3002\u30b5\u30eb\u75d8\u306b\u7279\u5fb4\u7684\u306a\u6240\u898b\u3068\u3057\u3066\u306f\u3001\u30ea\u30f3\u30d1\u7bc0\u816b\u8139\u304c\u60a3\u8005\u306b\u5171\u901a\u306b\u8a8d\u3081\u3089\u308c\u308b\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u81e8\u5e8a\u691c\u67fb\u6240\u898b<\/h3>\n

\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u7279\u7570\u7684\u691c\u67fb\u6240\u898b\u306f\u306a\u3044\u304c\u3001\u6025\u6027\u671f\u30ea\u30f3\u30d1\u7403\u6570\u306e\u6e1b\u5c11\u3084\u3001\u7570\u578b\u30ea\u30f3\u30d1\u7403\u6570\u306e\u5897\u591a\u306a\u3069\u3001\u521d\u611f\u67d3\u6642\u306e\u6025\u6027\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u3092\u8a8d\u3081\u308b\u3053\u3068\u304c\u591a\u3044(1)\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u78ba\u5b9a\u8a3a\u65ad<\/h3>\n

\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u306b\u3066\u75c5\u539f\u4f53\u30de\u30cb\u30e5\u30a2\u30eb<\/a>\u304c\u516c\u958b\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n

\u4e0a\u8ff0\u3057\u305f\u3088\u3046\u306b\u8840\u6e05\u8a3a\u65ad\u3067\u306f\u611f\u67d3\u3057\u305f\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u7a2e\u3092\u540c\u5b9a\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u78ba\u5b9a\u8a3a\u65ad\u306f\u75c5\u539f\u8a3a\u65ad\u306b\u3088\u308b\u3002\u6c34\u75b1\u3001\u81bf\u6ce1\u3001\u8840\u6db2\u3001\u30ea\u30f3\u30d1\u7bc0\u7b49\u304b\u3089\u306e\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u5206\u96e2\u306b\u3088\u308b\u75c5\u539f\u4f53\u306e\u691c\u51fa\u3042\u308b\u3044\u306f\u3001PCR\u6cd5\u3084Loop- Mediated Isothermal Amplification (LAMP) \u6cd5\u306b\u3088\u308b\u75c5\u539f\u4f53\u306e\u907a\u4f1d\u5b50\u306e\u691c\u51fa\u304c\u884c\u308f\u308c\u308b\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u691c\u51fa\u6cd5\u3067\u306f\u3001\u5f37\u6bd2\u578b\u306e\u30b3\u30f3\u30b4\u76c6\u5730\u578b\u3068\u3088\u308a\u5f31\u6bd2\u306a\u897f\u30a2\u30d5\u30ea\u30ab\u578b\u306e\u9451\u5225\u3082\u53ef\u80fd\u3067\u3042\u308b\uff082,3\uff09\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u6cbb\u7642<\/h3>\n

\u30b7\u30c9\u30d5\u30a9\u30d3\u30eb\u3001\u30b7\u30c9\u30d5\u30a9\u30d3\u30eb\u306e\u8a98\u5c0e\u4f53\u3067\u7d4c\u53e3\u6295\u4e0e\u53ef\u80fd\u306ahexadecloxypropyl-cidofovir (CMX001, Chimerix Inc.)\u3001 \u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u306e\u7d30\u80de\u5916\u611f\u67d3\u6027\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u5f62\u6210\u306e\u963b\u5bb3\u5264\u3067\u3042\u308bSIGA-246 (SIGA Technologies)\u7b49\u304c\u3001\u6700\u3082\u6709\u671b\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u3066\uff084,5,6\uff09\u3001\u7c73\u56fd\u3067\u81e8\u5e8a\u6cbb\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u305f\u30022022\u5e74\u3067\u306f\u30b7\u30c9\u30d5\u30a9\u30d3\u30eb\u3000Tcovirmat, Brincidofovir\u304c\u3001\u6b27\u5dde\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u65e5\u672c\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u7279\u7570\u7684\u6cbb\u7642\u85ac\u306f\u306a\u3044\u3002Tcovirmat\u306f2018\u5e74\u306b\u5929\u7136\u75d8\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066FDA\u3067\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u3001<\/p>\n

2022\u5e74\u306e\u8907\u6570\u306e\u975e\u30a8\u30f3\u30c7\u30df\u30c3\u30af\u56fd\u306b\u304a\u3051\u308b\u30a2\u30a6\u30c8\u30d6\u30ec\u30a4\u30af\u306b\u306e\u305f\u3081\u30012022\u5e746\u670829\u65e5Tcovirmat\u3092\u7279\u5b9a\u81e8\u5e8a\u7814\u7a76\u3068\u3057\u3066\u6295\u4e0e\u3067\u304d\u308b\u4f53\u5236\u3092\u6e96\u5099\u3057\u3066\u3044\u308b\u3002\u5fc5\u8981\u6642\u306f\u56fd\u7acb\u56fd\u969b\u7814\u7a76\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u3078\u76f8\u8ac7\u3059\u308b\u3002<\/p>\n

2022\u5e74\u30b5\u30eb\u75d8\u30a2\u30a6\u30c8\u30d6\u30ec\u30a4\u30af\u3078\u306e\u56fd\u5185\u5bfe\u5fdc<\/a>\u3078\u79fb\u52d5<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u4e88\u9632\uff08\u30ef\u30af\u30c1\u30f3\uff09<\/h3>\n

\u5929\u7136\u75d8\u306e\u30ef\u30af\u30c1\u30f3\u3067\u3042\u308b\u75d8\u305d\u3046\u30ef\u30af\u30c1\u30f3\u304c\u30a8\u30e0\u30dd\u30c3\u30af\u30b9(\u30b5\u30eb\u75d8)\u306b\u3082\u6709\u52b9\u3067\u3042\u308b\uff087\uff09\u3002\u611f\u67d3\u6570\u65e5\u4ee5\u5185\u306a\u3089\u3070\u6cbb\u7642\u7684\u306b\u4f7f\u7528\u3057\u3066\u3082\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u3057\u304b\u3057\u3001\u75d8\u305d\u3046\u30ef\u30af\u30c1\u30f3\u306f\u5e02\u8ca9\u3055\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u30b5\u30eb\u75d8\u306e\u4e88\u9632\u7528\u3068\u3057\u3066\u306e\u9069\u7528\u306f\u306a\u3044\u3002\u65e5\u672c\u3067\u306f\u30011968\u5e74\u4ee5\u524d\u306e\u51fa\u751f\u8005\u306f\uff12\u304b\u3089\uff13\u56de\u306e\u7a2e\u75d8\u6b74\u304c\u3042\u308a\u30011969\u304b\u30891975\u5e74\u306e\u51fa\u751f\u8005\u3067\u306f1\u56de\u306e\u7a2e\u75d8\u5bfe\u8c61\u3068\u306a\u3063\u3066\u3044\u308b\u3002\uff11\u56de\u7a2e\u75d8\u5bfe\u8c61\u8005\u306e\u63a5\u7a2e\u7387\u306f70%\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u30021976\u5e74\u4ee5\u964d\u306e\u51fa\u751f\u8005\u306f\u7a2e\u75d8\u5bfe\u8c61\u5916\u306e\u305f\u3081\u514d\u75ab\u304c\u306a\u3044\u3002\u7a2e\u75d8\u306e\u514d\u75ab\u6301\u7d9a\u671f\u9593\u306f\u4e0d\u660e\u3067\u3042\u308b\u304c\u3001\u65e5\u672c\u4eba\u306e\u7d041,000\u540d\u306e\u6297\u4f53\u8abf\u67fb\u3067\u306f\u3001\uff12\u56de\u4ee5\u4e0a\u306e\u7a2e\u75d8\u6b74\u304c\u3042\u308b\u5834\u5408\u3001\u7a2e\u75d8\u5f8c30\u5e74\u4ee5\u4e0a\u7d4c\u904e\u3057\u3066\u3082\u9ad8\u7387\u306b\u6297\u4f53\u304c\u4fdd\u6301\u3055\u308c\u3066\u3044\u305f\uff088\uff09\u3002\u3055\u3089\u306b\u3001\u30a6\u30a4\u30eb\u30b9\u7279\u7570\u7684\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\u306f\u7a2e\u75d8\u5f8c\u6570\u5341\u5e74\u5f8c\u3067\u3082\u9ad8\u7387\u306b\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\uff089\uff09<\/p>\n

2022\u5e74\u306e\u6d41\u884c\u306b\u95a2\u3057\u3066\u3001\u5929\u7136\u75d8\u30ef\u30af\u30c1\u30f3\u306e\u66dd\u9732\u5f8c\u4e88\u9632\u3092\u3001\u4e00\u90e8\u306e\u5bfe\u8c61\u8005\u306b\u5bfe\u3057\u3066\u3001\u56fd\u7acb\u56fd\u969b\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u7b49\u3067\u5b9f\u65bd\u3057\u3066\u304a\u308a\u3001\u66dd\u9732\u3059\u308b\u3088\u3046\u306a\u3053\u3068\u304c\u3042\u308c\u3070\u3001\u6700\u65b0\u306e\u60c5\u5831\u3092\u53d6\u308a\u5165\u308c\u5bfe\u5fdc\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n

 <\/p>\n

2022\u5e74\u306e\u6d41\u884c\u3067\u306f4-18%\u3067\u904e\u53bb\u306e\u5929\u7136\u75d8\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u8005\u306b\u304a\u3051\u308b\u611f\u67d3\u75c7\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a (10,11,12)\u3001\u56fd\u5185\u3067\u3082\u5b9a\u671f\u63a5\u7a2e\u4e16\u4ee3(1975\u5e74\u5ea6\u751f\u307e\u308c\u4ee5\u524d)\u3067\u611f\u67d3\u8005\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b (13)\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u30d0\u30a4\u30aa\u30cf\u30b6\u30fc\u30c9\u5bfe\u7b56<\/h3>\n

\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u306e\u53d6\u6271\u3044\u306f\u3001\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u306e\u5b89\u5168\u7ba1\u7406\u898f\u7a0b\u3067\u306fBSL2\uff08ABSL3\uff09\u3067\u3042\u308b\u304c\u3001\u3053\u308c\u306b\u52a0\u3048\u3066\u3001\u611f\u67d3\u75c7\u6cd5\u306b\u3088\u308b\u65bd\u8a2d\u306e\u57fa\u6e96\uff08\u611f\u67d3\u75c7\u6cd5\u7b2c56\u6761\u306e24\uff09\u3092\u6e80\u305f\u3057\u3066\u3044\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u611f\u67d3\u75c7\u6cd5\u306b\u304a\u3051\u308b\u53d6\u308a\u6271\u3044<\/h3>\n

\u30a8\u30e0\u30dd\u30c3\u30af\u30b9(\u30b5\u30eb\u75d8)\u306f\u3001\u611f\u67d3\u75c7\u6cd5\u30674\u985e\u611f\u67d3\u75c7\u306b\u6307\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002\u8a3a\u5bdf\u3042\u308b\u3044\u306f\u691c\u6848\u3057\u305f\u533b\u5e2b\u306e\u5224\u65ad\u306b\u3088\u308a\u3001\u60a3\u8005\uff08\u78ba\u5b9a\u4f8b\uff1a\u75c7\u72b6\u3084\u6240\u898b\u304b\u3089\u30b5\u30eb\u75d8\u304c\u7591\u308f\u308c\u3001\u78ba\u5b9a\u691c\u67fb\u306b\u3088\u3063\u3066\u75c5\u539f\u4f53\u306e\u8a3a\u65ad\u304c\u3055\u308c\u305f\u5834\u5408\uff09\u3001\u7121\u75c7\u72b6\u75c5\u539f\u4f53\u4fdd\u6709\u8005\uff08\u81e8\u5e8a\u7684\u7279\u5fb4\u3092\u5448\u3057\u3066\u3044\u306a\u3044\u304c\u3001\u78ba\u5b9a\u691c\u67fb\u306b\u3088\u308a\u3001\u75c5\u539f\u4f53\u306e\u8a3a\u65ad\u304c\u3055\u308c\u305f\u5834\u5408\uff09\u3001\u611f\u67d3\u75c7\u6b7b\u4ea1\u8005\u306e\u6b7b\u4f53\uff08\u75c7\u72b6\u3084\u6240\u898b\u304b\u3089\u30b5\u30eb\u75d8\u304c\u7591\u308f\u308c\u3001\u78ba\u5b9a\u691c\u67fb\u306b\u3088\u3063\u3066\u75c5\u539f\u4f53\u306e\u8a3a\u65ad\u304c\u3055\u308c\u305f\u5834\u5408\uff09\u3001\u611f\u67d3\u75c7\u6b7b\u4ea1\u7591\u3044\u8005\u306e\u6b7b\u4f53\uff08\u75c7\u72b6\u3084\u6240\u898b\u304b\u3089\u3001\u30b5\u30eb\u75d8\u306b\u3088\u308a\u6b7b\u4ea1\u3057\u305f\u3068\u7591\u308f\u308c\u308b\u5834\u5408\uff09\u3068\u8a3a\u65ad\u3055\u308c\u305f\u5834\u5408\u3001\u6cd5\u7b2c12\u6761\u7b2c1\u9805\u306e\u898f\u5b9a\u306b\u3088\u308b\u5c4a\u51fa\u3092\u76f4\u3061\u306b\u884c\u308f\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002
\n\u307e\u305f\u3001\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u611f\u67d3\u75c7\u6cd5\uff08\u653f\u4ee4\uff09\u30673\u7a2e\u75c5\u539f\u4f53\u306b\u6307\u5b9a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u30a6\u30a4\u30eb\u30b9\u3092\u6240\u6301\u3059\u308b\u5834\u5408\u306f\u3001\u611f\u67d3\u75c7\u6cd5\u7b2c56\u6761\u306e16\u306b\u3088\u308b\u6240\u6301\u306e\u5c4a\u51fa\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002\u307e\u305f\u3001\u904b\u642c\u306b\u3042\u305f\u3063\u3066\u306f\u611f\u67d3\u75c7\u6cd5\u7b2c56\u6761\u306e27\u306b\u3088\u308a\u90fd\u9053\u5e9c\u770c\u516c\u5b89\u59d4\u54e1\u4f1a\u3078\u306e\u5c4a\u51fa\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002<\/p>\n

\u6700\u65b0\u306e\u6271\u3044\u306b\u3064\u3044\u3066\u306f\u3001\u539a\u751f\u52b4\u50cd\u7701<\/a>\u306e\u8a72\u5f53\u30da\u30fc\u30b8\u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/p>\n

https:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/kenkou\/kekkaku-kansenshou19\/monkeypox_00001.html<\/p>\n

\u25b2TOP<\/a><\/p>\n

\u53c2\u8003\u6587\u732e<\/h3>\n
    \n
  1. 1. Adachi E, Saito M, Otani A, Koga M, Yotsuyanagi H: Transient decrease in T cells and atypical lymphocyte proliferation after the onset of mpox. J Med Virol. 2023 Aug;95(8):e29021<\/li>\n
  2. 2. Saijo M, Ami Y, Suzaki Y, Nagata N, Iwata N, Hasegawa H, Ogata M, Fukushi S, Mizutani T, Iizuka I, Sakai K, Sata T, Kurata T, Kurane I, Morikawa S. Diagnosis and assessment of monkeypox virus (MPXV) infection by quantitative PCR assay: differentiation of Congo Basin and West African MPXV strains. Jpn J Infect Dis. 61(2):140-2, 2008<\/li>\n
  3. 3. Iizuka I, Saijo M, Shiota T, Ami Y, Suzaki Y, Nagata N, Hasegawa H, Sakai K, Fukushi S, Mizutani T, Ogata M, Nakauchi M, Kurane I, Mizuguchi M, Morikawa S. Loop-mediated isothermal amplification-based diagnostic assay for monkeypox virus infections. J Med Virol. 81(6):1102-8, 2009<\/li>\n
  4. 4. Stittelaar KJ, Neyts J, Naesens L, van Amerongen G, van Lavieren RF, Hol\u00fd A, De Clercq E, Niesters HG, Fries E, Maas C, Mulder PG, van der Zeijst BA, Osterhaus AD. Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. Nature 439(7077):745-8, 2006<\/li>\n
  5. 5. Parker S, Touchette E, Oberle C, Almond M, Robertson A, Trost LC, Lampert B, Painter G, Buller RM. Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox model. Antiviral Res. 77(1):39-49, 2008<\/li>\n
  6. 6. Grosenbach DW, Berhanu A, King DS, Mosier S, Jones KF, Jordan RA, Bolken TC, Hruby DE.\u3000Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice.\u3000Proc Natl Acad Sci U S A. 107(2):838-43, 2010<\/li>\n
  7. 7. Saijo M, Ami Y, Suzaki Y, Nagata N, Iwata N, Hasegawa H, Ogata M, Fukushi S, Mizutani T, Sata T, Kurata T, Kurane I, and Morikawa S : LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox. J Virol. 80(11):5179-88, 2006<\/li>\n
  8. 8. Hatakeyama S, Moriya K, Saijo M, Morisawa Y, Kurane I, Koike K, Kimura S, and Morikawa S : Persisting humoral antiviral immunity within the Japanese population after the discontinuation in 1976 of routine smallpox vaccinations. Clin Diagn Lab Immunol. 12(4):520-4, 2005.<\/li>\n
  9. 9. Hammarlund E, Lewis MW, Hansen SG, Strelow LI, Nelson JA, Sexton GJ, Hanifin JM, Slifka MK.: Duration of antiviral immunity after smallpox vaccination. Nat. Med. 9: 1131\u20131137, 2003<\/li>\n
  10. 10. Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB, Palich R, Nori A, Reeves I, Habibi MS, Apea V, Boesecke C, Vandekerckhove L, Yakubovsky M, Sendagorta E, Blanco JL, Florence E, Moschese D, Maltez FM, Goorhuis A, Pourcher V, Migaud P, Noe S, Pintado C, Maggi F, Hansen AE, Hoffmann C, Lezama JI, Mussini C, Cattelan A, Makofane K, Tan D, Nozza S, Nemeth J, Klein MB, Orkin CM; SHARE-net Clinical Group.: Monkeypox Virus Infection in Humans across 16 Countries – April-June 2022. N Engl J Med. 2022 Aug 25;387(8):679-691<\/li>\n
  11. 11. Hazra A, Zucker J, Bell E, Flores J, Gordon L, Mitj\u00e0 O, Su\u00f1er C, Lemaignen A, Jamard S, Nozza S, Nori AV, P\u00e9rez-Barrag\u00e1n E, Rodr\u00edguez-Aldama JC, Blanco JL, Delaugerre C, Turner D, Fuertes I, Leiro V, Walmsley SL, Orkin CM; SHARE-NET writing group.: Mpox in people with past infection or a complete vaccination course: a global case series. Lancet Infect Dis. 2023 Sep 4:S1473-3099(23)00492-9<\/li>\n
  12. 12. Tar\u00edn-Vicente EJ, Alemany A, Agud-Dios M, Ubals M, Su\u00f1er C, Ant\u00f3n A, Arando M, Arroyo-Andr\u00e9s J, Calder\u00f3n-Lozano L, Casa\u00f1 C, Cabrera JM, Coll P, Descalzo V, Folgueira MD, Garc\u00eda-P\u00e9rez JN, Gil-Cruz E, Gonz\u00e1lez-Rodr\u00edguez B, Guti\u00e9rrez-Collar C, Hern\u00e1ndez-Rodr\u00edguez \u00c1, L\u00f3pez-Roa P, de Los \u00c1ngeles Mel\u00e9ndez M, Montero-Men\u00e1rguez J, Mu\u00f1oz-Gallego I, Palencia-P\u00e9rez SI, Paredes R, P\u00e9rez-Rivilla A, Pi\u00f1ana M, Prat N, Ramirez A, Rivero \u00c1, Rubio-Mu\u00f1iz CA, Vall M, Acosta-Vel\u00e1squez KS, Wang A, Galv\u00e1n-Casas C, Marks M, Ortiz-Romero PL, Mitj\u00e0 O: Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study. Lancet. 2022 Aug 27;400(10353):661-669. 2003<\/li>\n
  13. 13. Adachi E, Ikeuchi K, Otani A, Saito M, Koga M, Yotsuyanagi H.: Mpox associated with Panton-Valentin leucocidin-producing methicillin-resistant Staphylococcus aureus among people with HIV J Infect Chemother. 2023 Jul;29(7):710-712.<\/li>\n<\/ol>\n

    \u25b2TOP<\/a><\/p>\n

    \u753b\u50cf<\/h2>\n

    \"img_20120706161954\"<\/a>\u56f31 \u5929\u7136\u75d8\u30a6\u30a4\u30eb\u30b9\u306e\u96fb\u5b50\u9855\u5fae\u93e1\u5199\u771f.
    \n\u30d2\u30c8\u30b5\u30eb\u75d8\u60a3\u8005.<\/p>\n

    \"img_20120706162044\"<\/a>\u56f32 \u30d2\u30c8\u30b5\u30eb\u75d8\u60a3\u8005.
    \nDr. Muyembe-Tamfum JJ\u3088\u308a<\/p>\n

    \n","protected":false},"excerpt":{"rendered":"

    \u75c5\u539f\u4f53\u306e\u7279\u5fb4 \u30a8\u30e0\u30dd\u30c3\u30af\u30b9(\u30b5\u30eb\u75d8)\u306e\u75c5\u539f\u4f53\u306f\u3001\u30b5\u30eb\u75d8\u30a6\u30a4\u30eb\u30b9\u3067\u3001\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u79d1\u30aa\u30eb\u30bd\u30dd\u30c3\u30af\u30b9\u30a6\u30a4\u30eb\u30b9\u5c5e\u306b\u5206\u985e\u3055\u308c\u308b\u7d04200kbp\u306e\u4e8c\u672c\u9396DNA\u3092\u30b2\u30ce\u30e0\u3068\u3059\u308b\u3002\u30a6\u30a4\u30eb\u30b9\u306e\u5f62\u614b\u306f\u30ec\u30f3\u30ac\u72b6\u3067\u3001\u305d\u306e\u9577\u5f84\u306f300nm\u3092\u8d8a\u3048\u308b\u2026 \u7d9a\u304d\u3092\u8aad\u3080 »<\/a><\/span><\/p>\n","protected":false},"author":12,"featured_media":0,"parent":392,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/579"}],"collection":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/comments?post=579"}],"version-history":[{"count":22,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/579\/revisions"}],"predecessor-version":[{"id":1466,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/579\/revisions\/1466"}],"up":[{"embeddable":true,"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/pages\/392"}],"wp:attachment":[{"href":"https:\/\/h-crisis.niph.go.jp\/bt\/wp-json\/wp\/v2\/media?parent=579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}