Toshiro Tango, PhD.
Former Director, Visiting researcher, Department of Technology Assessment and Biostatistics, National Institute of Public Health.


Research Interests:

  • Statistical Methods for Medical Research
  • Spatial Epidemiology (Disease Clustering)
  • Geographical Disease Surveillance
  • Clinical Trials - Design and Statistical Analysis
  • Environmental Health problems
  • Nutritional Epidemiology, etc.


    Selected Publications:

  • Tango T. Statistical Methods for Disease Clustering, Statistics for Biology and Health Series, New York, Springer (2010)

  • Tango T, Takahashi K and Kohriyama K. A space-time scan statistic for detecting emerging outbreaks. Biometrics 2010 (In press).

  • Nishikawa M, Tango T. Ohtaki M. Statistical tests based on new composite hypotheses in clinical trials reflecting the relative clinical importance of multiple endpoints quantitatively. Biometrical Journal 2009; 51:749-762.

  • Tango T. Sample size formula for randomized controlled trials with counts of recurrent events. Statistics and Probability Letters. 2009; 79: 466-472.

  • Hasegawa T, Tango T. Permutation test following covariate-adaptive randomization in randomized controlled trials. Journal of Biopharmaceutical Statistics, 2009; 19: 106-119.

  • Tango T. A spatial scan statistic with a restricted likelihood ratio. Japanese Journal of Biometrics 2008; 29:75-95.

  • Ishizuka B, Kudo Y, Tango T. Cross-sectional community survey of menopause symptoms among Japanese women. Maturitas, 2008; 61: 260-267.

  • Takahashi K, Kulldorff M, Tango T and Yih K. A flexibly shaped space-time scan statistic for disease outbreak detection and monitoring. International Journal of Health Geographics 2008; 7:14.

  • Doi Y, Yokoyama T, Sakai M, Nakamura Y, Tango T and Takahashi K. Spatial clusters of Creutzfeldt-Jakob disease mortality in Japan between 1995 and 2004. Neuroepidemiology 2008; 30:222-228.

  • Tango T. A class of multiplicity-adjusted tests for spatial clustering based on case-control point data, Biometrics, 2007; 63: 119-127.

  • Mitani S, Kamata H, Fujiwara M, Aoki N, Okada S, Watanabe M, Tango T and Mori S. Missense mutation with/without nonsense mutation of the p53 gene is associated with large cell morphology in human malignant lymphoma. Pathology International, 2007; 57: 430-436.

  • Takahashi K and Tango T. An extended power of cluster detection tests. Statistics in Medicine 2006; 25: 841-852.

  • Nishikawa M, Tango T, Ogawa M. Non-Parametric inference of adverse events under informative censoring. Statistics in Medicine, 2006; 25: 3981-4003.

  • Nishikawa M and Tango T. Letter to the editor - "Testing treatment effects in the presence of competing risks. Statistics in Medicine, 2006; 25: 3758-3760.

  • Aida J, Ando Y, Aoyama H, Tango T, Morita M. An ecological study on the association of public dental health activities and sociodemographic characteristics with caries prevalence in Japanese 3-year-old children. Caries Research, 2006; 40: 466-472.

  • Tango T. Linear equations with random variables. Statistics in Medicine. 2005; 24: 3213-3222.

  • Yamaoka K and Tango T. Efficacy of lifestyle education to prevent type 2 diabetes - A meta-analysis of randomized controlled trials. Diabetes Care. 2005; 28: 2780-2786.

  • Tango T and Takahashi K. A flexibly shaped spatial scan statistic for detecting clusters. International Journal of Health Geographics. 2005; 4: 11.

  • Tango T, Fujita T, Tanihata T, Minowa M, Doi Y, Kato N, Kunikane S, Uchiyama I, Tanaka M and Uehata T. Risk of adverse reproductive outcomes associated with proximity to municipal solid waste incinerators with high dioxin emission levels in Japan. Journal of Epidemiology. 2004; 14: 83-93.

  • Watanabe M, Yamaoka K, Yokotsuka M, Tango T. Randomized controlled trial of a new dietary education program to prevent type 2 diabetes in a high-risk group of Japanese male workers, Diabetes Care. 2003; 26F3209-3214.

  • Nishikawa M and Tango T. Counter-intuitive Properties of the Kaplan-Meier Estimator. Statistics and Probability Letters. 2003; 65: 353-361.

  • Nishikawa M and Tango T. Behavior of the Kaplan-Meier Estimator for deterministic imputations to interval-censored data and the Turnbull estimator. Japanese Journal of Biometrics. 2003; 24(2):71-94.

  • Kulldorff M, Tango T and Park PJ. Power comparisons for disease clustering tests. Computational Statistics and Data Analysis 2003; 42: 665-684.

  • Doi Y, Minowa M, Tango, T. Impact and correlates of poor sleep quality in Japanese white-color employees. Sleep. 2003; 26: 467-471.

  • Kawashima M, Tango, T, Noguchi T, Inagi M, Nakagawa H and Harada S. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicenter, double-blind, placebo-controlled, parallel-group study. British Journal of Dermatology. 2003; 148: 1212-1221.

  • Iwasaki, T, Murata M, Ohshima S, Miyake T, Kudo S, Inoue Y, Narita M, Yoshimura T, Akiba S, Tango T, Yoshimoto Y, Shimizu Y, Sobue T, Kusumi S, Yamagishi C and Matsudaira H. Second analysis of mortality of Nuclear Industry workers in Japan, 1986-1997. Radiation Rsearch. 2003; 159:228-238.

  • Daida H, Ouchi Y, Saito Y, Yamada N, Nishide T, Mokuno H, Kurata T, Sato H, Eto M, Ako J, Tango T. and Yamaguchi H. Preventing angiograhic progression of coronary atherosclerosis with pravastatin. Journal of Atherosclerosis and Thrombosis. 2003: 10: 25-31.

  • Tango T. Score tests for detecting excess risks around putative sources. Statistics in Medicine. 2002; 21: 497-514.

  • Murata M, Miyake T, Inoue Y, Ohshima S, Kudo S, Yoshimura T, Akiba S, Tango T, Yoshimoto Y, Shimizu Y, Sobue T, Kusumi S, Iwasaki T, Yamagishi C and Matsudaira H. Life-style and other characteristics of radiation workers at nuclear facilities in Japan: Base-line data of a questionnaire survey. J. Epidemiology. 2002; 12: 310-319.

  • Miyake K, Tango, T, Ota Y, Mitamura K, Yoshiba M, Kako M, Hayashi S, Ikeda Y, Hayashida N, Iwabuchi S, Sato Y, Tomi T, Funaki N, Hashimoto N, Umeda T, Miyazaki J, Tanaka K, Endo Y and Suzuki H. Efficacy of stronger neo-minophagen between two doses administered three times a week on patients with chronic viral hepatitis. J. Gatroenterology and Hepatology. 2002; 17: 1198-1204.

  • Kawashima M, Harada S and Tango T. Review of fexofenadine in the treatment of chronic idiopathic urticaria. The International Journal of Dermatology. 2002; 41: 701-706.

  • Takahashi M and Tango T. Estimation of excess mortality associated with influenza-epidemics by age and cause specific death in Japan, 1975-1999. Japanese Journal of Hygine. 2002; 57: 571-584 (in Japanese).

  • Iino S, Tango T, Matsushima T, Toda G, Miyaka K, Hino K, Kumada H, Yasuda, K, Kuroki T, Hirayama C and Suzuki H. Therapeutic effects of stronger neo-minophagen C at different doses on chronic hepatitis and liver cirrhosis. Hepatology Research. 2001; 19: 31-40.

  • Mitani S, Kamata H, Fujiwara M, Aoki N, Tango T, Fukuchi K, Oka T. Analysis of c-myc DNA amplification in non-small cell lung carcinoma in comparison wiht small cell lung carcinoma using polymerase chain reaction. Clin Exp Med. 2001; 2: 105-111.

  • Takahashi M and Tango T. Comparison study of new method and the Kawai and Fukutomi methods for estimating excess mortality associated with influenza-epidemics, based upon National vital statistics from 1975 to 1997. Japanese Journal of Public Health. 2001; 48: 816-826 (in Japanese).

  • Takahashi M and Tango T. A proposal for a new definition of excess mortality associated with influenza-epidemics and its estimation. Japanese Journal of Public Health. 2001; 48: 402-408 (in Japanese).

  • Tango T. Confidence intervals for differences in correlated binary proportions (with Author's Reply). Statistics in Medicine. 2000; 19, 133-139.

  • Tango T. A test for spatial disease clustering adjusted for multiple testing. Statistics in Medicine. 2000; 19: 191-204.

  • Mori H, Taketani Y, Uemura T, Miyake A, and Tango T. Rates of endometriosis recurrence and pregnancy 1 year after treatment with intranasal Buserelin Acetate (A prospective study). J. Obstet. Gynaecol. Res. 1999; 25: 153-164.

  • Tango T. Comparison of general tests for disease clustering. in "Disease Mapping and Risk Assessment for Public Health (Lawson A. et al. eds), John Wiley & Sons, 1999; 111-117.

  • Tango T. Improved confidence intervals for the difference between binomial proportions based on paired data (with Author's Reply). Statistitics in Medicine. 1999; 18, 3511-3513.

  • Tango T. Equivalence test and confidence interval for the difference in proportions for the paired-sample design. Statistics in Medicine. 1998; 17: 891-908.

  • Tango T. Estimation of age-specific reference ranges via smoother AVAS. Statistics in Medicine. 1998; 17: 1231-1243.

  • Tango T. A mixture model to classify individual profiles of repeated measurements. In "Data Science, Classification and Related Topics (eds by C. Hayashi, et al.), Springer-Verlag, Tokyo, 1998; 247-254.

  • Tango T. Adjusting Moran's I for population density. Statistics in Medicine. 1998; 17: 1055-1062.

  • Tango T, Maximum likelihood estimation of date of infection in an outbreak of diarrhea due to contaminated foods assuming lognormal distribution for the incubation period. Japanese Journal of Public Health. 1998; 45: 129-141.