Department of Environmental Health

 

Chief Senior Researcher
SHIMURA Tsutomu

Specialty

Radiation biology, Radiation hygiene, Molecular biology

Works

Original papers

1 Shimura T, Sunaga K, Yamazaki M, Nara H, Sasatani M, Kamiya K, Ushiyama A Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response Int. J Radiat. Biol. 2024;100(4): 584-594.

2 Shimura T, Totani R, Ogasawara H, Inomata K, Sasatani M, Ushiyama A, et al. Effects of oxygen on the response of mitochondria to X-irradiation and reactive oxygen species-mediated fibroblast activation. International Journal of Radiation Biology. 2023;99(5):769-778.

3 Shimura T, Shiga R, Sasatani M, Kamiya K, Ushiyama A. Melatonin and MitoEbselen-2 Are Radioprotective Agents to Mitochondria. Genes. 2023;14(1):45.

4 Shimura T, Nakashiro C, Fujiwara K, Shiga R, Sasatani M, Ushiyama A, et al. Radiation affects glutathione redox reaction by reduced glutathione peroxidase activity in human fibroblasts. J Radiat Res. 2022;63(2):183-191.

5 Shimura T, Ando T, Narao M, Sasatani M, Kamiya K, Ushiyama A. Mechanism of turnover or persistence of radiation-induced myofibroblast in vitro. 2020; Cell Cycle.19 (23), 3375-3385

6 Shimura T, Nakashiro C, Narao M, Ushiyama A. Induction of oxidative stress biomarkers following whole-body irradiation in mice. PLoS One. 2020; 15(10):e0240108. doi: 10.1371/journal.pone.0240108.

Reviews

1 Shimura T. Mitochondrial Signaling Pathways Associated with DNA Damage Responses. Int. J. Mol. Sci. 2023;24(7):6128.

2 Shimura T. ATM-Mediated Mitochondrial Radiation Responses of Human Fibroblasts. Genes 2021; 12(7).

3 Shimura T. Roles of Fibroblasts in Microenvironment Formation Associated with Radiation-Induced Cancer. Advances in experimental medicine and biology Tumor microenvironment: Novel Concepts 2021; 1329 239-251.

4 Shimura T, YAMAGUCHI I, TERADA H,YUNOKAWA T, USHIYAMA A Biological effects of tritium and the issue of radiation effects at low-doses J. Natl. Inst. Public Health, 2021;.70 (.2), 160-165

Social contributions

Journal of Radiation Research, Associate editor

Scientific Reports, Editorial Board member