専門分野

分析化学

人材育成

短期研修
1 医薬品医療機器の品質確保に関する研修　副主任
2 たばこ対策の施策推進における企画・調整のための研修　副主任
3 環境衛生監視指導研修　副主任

研究実績

原著論文

1 Nishimoto-Kusunose S, Hirakawa A, Tanaka A, Yoshizawa K, Makino K, Takahashi H, Higashi T. Drugs possessing aryloxypropanamine pharmacophore, duloxetine, dapoxetine and propranolol, increase allopregnanolone in rat brain: Possible involvement of allopregnanolone in their central nervous system effects. Steroids. 2023 Jul 17:109272. doi: 10.1016/j.steroids.2023.109272. Epub ahead of print.

2 Shibuya T, Nishimoto-Kusunose S, Hirakawa A, Yoshizawa K, Higashi T. LC/ESI-MS/MS analysis of progesterone-derived steroids produced in SH-SY5Y cells. Med Mass Spectrom. 2023 Jun;7(1):60-70. doi: 10.24508/mms.2023.06.007②

3 Higashi T, Aso S, Horisaki H, Ito T, Tanaka S, Nishimoto-Kusunose S, Ogawa S, Kato K, Ide H. Evaluation of thumbnail clipping as a specimen for retrospectively assessing average production of testosterone. Clin Chim Acta. 2023 Jan 1;538:157-163. doi: 10.1016/j.cca.2022.11.019.

4 Takada K, Hagiwara Y, Togashi M, Kittaka A, Kawagoe F, Uesugi M, Nishimoto-Kusunose S, Higashi T. 23,25-Dihydroxyvitamin D3 is liberated as a major vitamin D3 metabolite in human urine after treatment with β-glucuronidase: Quantitative comparison with 24,25-dihydroxyvitamin D3 by LC/MS/MS. J Steroid Biochem Mol Biol. 2022 Oct;223:106133. doi: 10.1016/j.jsbmb.2022.106133.

5 Fujimura S, Ito T, Ogawa S, Ishige T, Nishimoto-Kusunose S, Higashi T. An LC/MS/MS method for quantifying testosterone and dehydroepiandrosterone sulfate in four different serum samples during a single run. Anal Sci. 2022 Jan;38(1):167-173. doi: 10.2116/analsci.21P268.

6 Nishimoto-Kusunose S, Sawa M, Inaba Y, Ushiyama A, Ishii K, Hattori K, Ogasawara Y. Exposure to aerosol extract from heated tobacco products causes a drastic decrease of glutathione and protein carbonylation in human lung epithelial cells. Biochem Biophys Res Commun. 2022 Jan 22;589:92-99. doi: 10.1016/j.bbrc.2021.12.004.

7 Ohta A, Hobo W, Ogawa S, Sugiura Y, Nishikawa T, Nishimoto K, Nishimoto-Kusunose S, Higashi T. A method for determination of aldosterone concentrations of six adrenal venous serum samples during a single LC/ESI-MS/MS run using a sextet of Girard reagents. J Pharm Biomed Anal. 2022 Jan 5;207:114423. doi: 10.1016/j.jpba.2021.114423.

8 Koike S, Miyaji Y, Sano H, Aikawa N, Kai M, Kasahara S, Suzuki T, Nishimoto-Kusunose S, Ogasawara Y. Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer’s Disease in Mouse Brain and Plasma. Anal Sci. 2021 Aug 10;37(8):1165-1170. doi: 10.2116/analsci.20P429.

9 Aso S, Ogawa S, Nishimoto-Kusunose S, Satoh M, Ishige T, Nomura F, Higashi T. Derivatization-based quadruplex LC/ESI-MS/MS method for high throughput quantification of serum dehydroepiandrosterone sulfate. Biomed Chromatogr. 2021 Apr;35(4):e5027. doi: 10.1002/bmc.5027.

総説

1 楠瀬翔一. 神経ステロイドの質量分析による解析法と創薬への展開. JSBMS Letters. 2021;46:20-25.