専門分野

放射線生物学、放射線衛生学、分子生物学

人材育成

専門課程
1 保健福祉行政管理分野分割前期（基礎）　環境保健概論、健康危機管理 /感染症　科目担当者

短期研修
1 医療放射線の適正管理に関する研修　主任
2 食品衛生監視指導研修　副主任
3 建築物衛生研修　副主任

研究実績

原著論文

1 Shimura T, Takahashi Y, Saito C, Maida R, Sasatani M, Kunoh T, Ushiyama A. Ionizing radiation triggers the release of mitochondrial DNA into the cytosol as a signal of mitochondrial damage. Scientific reports 15(1) 23191-23191

2 Shimura T, Nara H, Yamazaki M, Sasatani M, Ushiyama A. Suppression of cancer stem-like cell radioresistance by inhibiting AMPK signaling. Journal of radiation research 66(3) 227-233

3 Shimura T, Ushiyama A. Mitochondrial reactive oxygen species-mediated fibroblast activation has a role in tumor microenvironment formation in radiation carcinogenesis. Radiation protection dosimetry 200(16-18) 1590-1593

4 Shimura T, Sunaga K, Yamazaki M, Nara H, Sasatani M, Kamiya K, Ushiyama A Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response. Int. J Radiat. Biol. 2024;100(4): 584-594.

5 Shimura T, Totani R, Ogasawara H, Inomata K, Sasatani M, Ushiyama A, et al. Effects of oxygen on the response of mitochondria to X-irradiation and reactive oxygen species-mediated fibroblast activation. International Journal of Radiation Biology. 2023;99(5):769-778.

6 Shimura T, Shiga R, Sasatani M, Kamiya K, Ushiyama A. Melatonin and MitoEbselen-2 Are Radioprotective Agents to Mitochondria. Genes. 2023;14(1):45.

総説

1 Shimura T. Mitochondrial Signaling Pathways Associated with DNA Damage Responses. Int. J. Mol. Sci. 2023;24(7):6128.

2 Shimura T. ATM-Mediated Mitochondrial Radiation Responses of Human Fibroblasts. Genes 2021; 12(7).

3 Shimura T. Roles of Fibroblasts in Microenvironment Formation Associated with Radiation-Induced Cancer. Advances in experimental medicine and biology Tumor microenvironment: Novel Concepts 2021; 1329 239-251.

4 志村勉，山口一郎，寺田宙，温泉川肇彦，牛山明 トリチウムの生体への影響と低線量放射線影響研究の課題 保健医療科学　2021;.70 (.2), 160－165

社会貢献

・薬事・食品衛生審議会臨時委員

・日本放射線影響学会　学会誌　Journal of Radiation Researchの編集委員

・雑誌Scientific ReportsのEditorial Board member

・公益財団法人環境科学技術研究所　低線量率放射線に対する生理応答影響実験調査（第2期）委員